PUBLICATION
Altechromone A Ameliorates Inflammatory Bowel Disease by Inhibiting NF-κB and NLRP3 Pathways
- Authors
- Li, L., Huang, J., Feng, L., Xu, L., Lin, H., Liu, K., Li, X., Wang, R.
- ID
- ZDB-PUB-240928-1
- Date
- 2024
- Source
- Marine drugs 22(9): (Journal)
- Registered Authors
- Keywords
- Altechromone A, NOD pathway, anti-inflammatory activity, inflammatory bowel disease, zebrafish
- MeSH Terms
-
- Inflammatory Bowel Diseases*/drug therapy
- Reactive Oxygen Species/metabolism
- Penicillium chrysogenum/drug effects
- Signal Transduction/drug effects
- Animals
- NF-kappa B*/metabolism
- Zebrafish*
- NLR Family, Pyrin Domain-Containing 3 Protein*/antagonists & inhibitors
- NLR Family, Pyrin Domain-Containing 3 Protein*/metabolism
- Disease Models, Animal*
- Anti-Inflammatory Agents*/pharmacology
- PubMed
- 39330291 Full text @ Mar. Drugs
Citation
Li, L., Huang, J., Feng, L., Xu, L., Lin, H., Liu, K., Li, X., Wang, R. (2024) Altechromone A Ameliorates Inflammatory Bowel Disease by Inhibiting NF-κB and NLRP3 Pathways. Marine drugs. 22(9):.
Abstract
Altechromone A, also known as 2,5-dimethyl-7-hydroxychromone, is a hydroxyketone containing one hydroxyl and one ketone group. In this study, we isolated Altechromone A from the marine-derived fungus Penicillium Chrysogenum (XY-14-0-4). Previous reports show that Altechromone A has various activities including tumor suppression, antibacterial, and antiviral activities. However, there is no study about its anti-inflammatory activity in inflammatory bowel disease (IBD). Here, we assess the anti-inflammatory activity, especially in IBD, and its potential mechanism using the zebrafish model. Our results indicated that Altechromone A has anti-inflammatory activity in a CuSO4-, tail-cutting-, and LPS-induced inflammatory model in zebrafish, respectively. In addition, Altechromone A greatly reduced the number of neutrophils, improved intestinal motility and efflux efficiency, alleviated intestinal damage, and reduced reactive oxygen species production in the TNBS-induced IBD zebrafish model. The transcriptomics sequencing and real-time qPCR indicated that Altechromone A inhibited the expression of pro-inflammatory genes including TNF-α, NF-κB, IL-1, IL-1β, IL-6, and NLRP3. Therefore, these data indicate that Altechromone A exhibits therapeutic effects in IBD by inhibiting the inflammatory response.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping