PUBLICATION
Petrosamine isolated from marine sponge Petrosia sp. demonstrates protection against neurotoxicity in vitro and in vivo
- Authors
- Ribeiro, J., Araújo-Silva, H., Fernandes, M., da Silva, J.A., Pinto, F.D.C.L., Pessoa, O.D.L., Santos, H.S., de Menezes, J.E.S.A., Gomes, A.C.
- ID
- ZDB-PUB-240222-25
- Date
- 2024
- Source
- Natural products and bioprospecting 14: 1616 (Journal)
- Registered Authors
- Keywords
- Aluminium-induced neurotoxicity, Neuroprotection, Petrosamine, Petrosia sp.
- MeSH Terms
- none
- PubMed
- 38383833 Full text @ Nat Prod Bioprospect
Citation
Ribeiro, J., Araújo-Silva, H., Fernandes, M., da Silva, J.A., Pinto, F.D.C.L., Pessoa, O.D.L., Santos, H.S., de Menezes, J.E.S.A., Gomes, A.C. (2024) Petrosamine isolated from marine sponge Petrosia sp. demonstrates protection against neurotoxicity in vitro and in vivo. Natural products and bioprospecting. 14:1616.
Abstract
According to The World Alzheimer Report 2023 by Alzheimer's Disease International (ADI) estimates that 33 to 38.5 million people worldwide suffer from Alzheimer's Disease (AD). A crucial hallmark associated with this disease is associated with the deficiency of the brain neurotransmitter acetylcholine, due to an affected acetylcholinesterase (AChE) activity. Marine organisms synthesize several classes of compounds, some of which exhibit significant AChE inhibition, such as petrosamine, a coloured pyridoacridine alkaloid. The aim of this work was to characterize the activity of petrosamine isolated for the first time from a Brazilian marine sponge, using two neurotoxicity models with aluminium chloride, as exposure to aluminium is associated with the development of neurodegenerative diseases. The in vitro model was based in a neuroblastoma cell line and the in vivo model exploited the potential of zebrafish (Danio rerio) embryos in mimicking hallmarks of AD. To our knowledge, this is the first report on petrosamine's activity over these parameters, either in vitro or in vivo, in order to characterize its full potential for tackling neurotoxicity.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping