PUBLICATION
Colonization of larval zebrafish (Danio rerio) with adherent-invasive Escherichia coli prevents recovery of the intestinal mucosa from drug-induced enterocolitis
- Authors
- Flores, E., Dutta, S., Bosserman, R., van Hoof, A., Krachler, A.-.M.
- ID
- ZDB-PUB-231118-2
- Date
- 2023
- Source
- mSphere 8(6): e0051223 (Journal)
- Registered Authors
- Keywords
- AIEC, colitis, intestinal colonization, zebrafish
- MeSH Terms
-
- Zebrafish
- Animals
- Escherichia coli/genetics
- Inflammatory Bowel Diseases*
- Crohn Disease*/complications
- Humans
- Enterocolitis*/complications
- Colitis*/chemically induced
- Escherichia coli Infections*
- Intestinal Mucosa
- PubMed
- 37971273 Full text @ mSphere
Citation
Flores, E., Dutta, S., Bosserman, R., van Hoof, A., Krachler, A.-.M. (2023) Colonization of larval zebrafish (Danio rerio) with adherent-invasive Escherichia coli prevents recovery of the intestinal mucosa from drug-induced enterocolitis. mSphere. 8(6):e0051223.
Abstract
Although inflammatory bowel diseases are on the rise, what factors influence IBD risk and severity, and the underlying mechanisms remain to be fully understood. Although host genetics, microbiome, and environmental factors have all been shown to correlate with the development of IBD, cause and effect are difficult to disentangle in this context. For example, AIEC is a known pathobiont found in IBD patients, but it remains unclear if gut inflammation during IBD facilitates colonization with AIEC, or if AIEC colonization makes the host more susceptible to pro-inflammatory stimuli. It is critical to understand the mechanisms that contribute to AIEC infections in a susceptible host in order to develop successful therapeutics. Here, we show that the larval zebrafish model recapitulates key features of AIEC infections in other animal models and can be utilized to address these gaps in knowledge.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping