PUBLICATION
Chlorahololide D, a Lindenane-Type Sesquiterpenoid Dimer from Chloranthus holostegius Suppressing Breast Cancer Progression
- Authors
- Li, Y., Liu, W., Xu, J., Guo, Y.
- ID
- ZDB-PUB-231029-62
- Date
- 2023
- Source
- Molecules 28(20): (Journal)
- Registered Authors
- Keywords
- Chloranthus holostegius, FAK, breast cancer, lindenane-type sesquiterpenoid dimer, zebrafish model
- MeSH Terms
-
- Cell Proliferation
- MCF-7 Cells
- Breast Neoplasms*/drug therapy
- Magnoliopsida*/metabolism
- Animals
- Molecular Structure
- Zebrafish/metabolism
- Apoptosis
- Sesquiterpenes*
- Humans
- Female
- Cell Line, Tumor
- PubMed
- 37894550 Full text @ Molecules
Citation
Li, Y., Liu, W., Xu, J., Guo, Y. (2023) Chlorahololide D, a Lindenane-Type Sesquiterpenoid Dimer from Chloranthus holostegius Suppressing Breast Cancer Progression. Molecules. 28(20):.
Abstract
Aimed at discovering small molecules as anticancer drugs or lead compounds from plants, a lindenane-type sesquiterpene dimer, chlorahololide D, was isolated from Chloranthus holostegius. The literature review showed that there were few reports on the antitumor effects and mechanisms of chlorahololide D. Our biological assay suggested that chlorahololide D blocked the growth and triggered apoptosis of MCF-7 cells by stimulating the reactive oxygen species (ROS) levels and arresting the cell cycle at the G2 stage. Further mechanism exploration suggested that chlorahololide D regulated apoptosis-related proteins Bcl-2 and Bax. Moreover, chlorahololide D inhibited cell migration by regulating the FAK signaling pathway. In the zebrafish xenograft model, chlorahololide D was observed to suppress tumor proliferation and migration significantly. Considering the crucial function of angiogenesis in tumor development, the anti-angiogenesis of chlorahololide D was also investigated. All of the research preliminarily revealed that chlorahololide D could become an anti-breast cancer drug.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping