PUBLICATION
Estrogenic and non-estrogenic effects of bisphenol A and its action mechanism in the zebrafish model: An overview of the past two decades of work
- Authors
- Yuan, M., Chen, S., Zeng, C., Fan, Y., Ge, W., Chen, W.
- ID
- ZDB-PUB-230528-29
- Date
- 2023
- Source
- Environment International 176: 107976107976 (Review)
- Registered Authors
- Chen, Weiting, Fan, Yuqin, Ge, Wei
- Keywords
- Bisphenol A, Epigenetics, Estrogenic effects, Non-estrogenic effects, Oxidative stress, Transgenerational inheritance, Zebrafish
- MeSH Terms
-
- Animals
- Benzhydryl Compounds/metabolism
- Benzhydryl Compounds/toxicity
- Endocrine Disruptors*/metabolism
- Endocrine Disruptors*/toxicity
- Estrone
- Humans
- Phenols/metabolism
- Phenols/toxicity
- Zebrafish*/metabolism
- PubMed
- 37236126 Full text @ Environ. Int.
Citation
Yuan, M., Chen, S., Zeng, C., Fan, Y., Ge, W., Chen, W. (2023) Estrogenic and non-estrogenic effects of bisphenol A and its action mechanism in the zebrafish model: An overview of the past two decades of work. Environment International. 176:107976107976.
Abstract
Bisphenol A (BPA) is the most simple and predominant component of the Bisphenol family. BPA is widely present in the environment and the human body as a result of its extensive usage in the plastic and epoxy resins of consumer goods like water bottles, food containers, and tableware. Since the 1930s, when BPA's estrogenic activity was first observed, and it was labeled as a "mimic hormone of E2", studies on the endocrine-disrupting effects of BPA then have been widely conducted. As a top vertebrate model for genetic and developmental studies, the zebrafish has caught tremendous attention in the past two decades. By using the zebrafish, the negative effects of BPA either through estrogenic signaling pathways or non-estrogenic signaling pathways were largely found. In this review, we tried to draw a full picture of the current state of knowledge on the estrogenic and non-estrogenic effects of BPA with their mechanisms of action through the zebrafish model of the past two decades, which may help to fully understand the endocrine-disrupting effects of BPA and its action mechanism, and give a direction for the future studies.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping