PUBLICATION

Ventricular Anisotropic Deformation and Contractile Function of the Developing Heart of Zebrafish in-vivo

Authors
Salehin, N., Teranikar, T., Lee, J., Chuong, C.J.
ID
ZDB-PUB-220907-26
Date
2022
Source
Developmental Dynamics : an official publication of the American Association of Anatomists   252(2): 247-262 (Journal)
Registered Authors
Lee, Juhyun
Keywords
Cardiac development, ventricle, ventricular deformation, ventricular function, ventricular trabeculae, zebrafish embryos
MeSH Terms
  • Heart*
  • Animals
  • Heart Ventricles
  • Cardiac Output
  • Anisotropy
  • Zebrafish*
(all 6)
PubMed
36057940 Full text @ Dev. Dyn.
Abstract
Background The developing zebrafish ventricle generates higher intraventricular pressure (IVP) with increasing stroke volume and cardiac output at different developmental stages to meet the metabolic demands of the rapidly growing embryo1 . To understand the changing role of the developing embryonic heart, we studied its biomechanical characteristics during in vivo cardiac cycles. By combining changes in wall strains and IVP measurements, we assessed ventricular wall stiffness during diastolic filling and the ensuing systolic IVP-generation capacity during 3, 4, and 5 days-post-fertilization (dpf). We further examined the anisotropy of wall deformation, in different regions within the ventricle, throughout a complete cardiac cycle.
Results We found the ventricular walls grow increasingly stiff during diastolic filling with a corresponding increase in IVP-generation capacity from 3-, to 4-, to 5-dpf group. Additionally, we found the corresponding increasing level of anisotropic wall deformation through cardiac cycles that favor the latitudinal direction, with the most pronounced found in the equatorial region of the ventricle.
Conclusions From 3-, to 4-, to 5-dpf, the ventricular wall myocardium undergoes increasing level of anisotropic deformation. This, in combination with the increasing wall stiffness and IVP-generation capacity, allows the developing heart to effectively pump blood to meet the rapidly growing embryo's needs. This article is protected by copyright. All rights reserved.
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    Citation
    Salehin, N., Teranikar, T., Lee, J., Chuong, C.J. (2022) Ventricular Anisotropic Deformation and Contractile Function of the Developing Heart of Zebrafish in-vivo. Developmental Dynamics : an official publication of the American Association of Anatomists. 252(2):247-262.