PUBLICATION
Cratoxylumxanthone C, a natural xanthone, inhibits lung cancer proliferation and metastasis by regulating STAT3 and FAK signal pathways
- Authors
- Li, Y., Wang, H., Liu, W., Hou, J., Xu, J., Guo, Y., Hu, P.
- ID
- ZDB-PUB-220827-32
- Date
- 2022
- Source
- Frontiers in pharmacology 13: 920422 (Journal)
- Registered Authors
- Keywords
- FAK, anti-tumor, cratoxylumxanthone C, natural xanthone, stat3, zebrafish
- MeSH Terms
- none
- PubMed
- 36016565 Full text @ Front Pharmacol
Citation
Li, Y., Wang, H., Liu, W., Hou, J., Xu, J., Guo, Y., Hu, P. (2022) Cratoxylumxanthone C, a natural xanthone, inhibits lung cancer proliferation and metastasis by regulating STAT3 and FAK signal pathways. Frontiers in pharmacology. 13:920422.
Abstract
To discover phytochemicals as lead compounds for cancer treatment, cratoxylumxanthone C, a natural xanthone, was obtained from Cratoxylum cochinchinense (Lour.) Bl., for which there have been no reports on the biological effects against cancer. Our study revealed that cratoxylumxanthone C had significant anti-tumor activity by inducing apoptosis, augmenting cellular reactive oxygen species (ROS), and arresting cell circle. The mechanistic examination showed the inhibition of A549 cell proliferation and metastasis by cratoxylumxanthone C was coupled with the signal transducer and activator of transcription 3 (STAT3) and focal adhesion kinase (FAK) signaling pathways. Furthermore, the zebrafish models confirmed its significant in vivo anti-tumor activity, in which cratoxylumxanthone C inhibited tumor proliferation and metastasis and suppressed the angiogenesis. Comprehensively, these cellular and zebrafish experiments implied that cratoxylumxanthone C may have the potential to become an anti-tumor agent for lung cancer, especially non-small cell lung cancer (NSCLC).
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping