PUBLICATION
Cranberry Pomace Extract Exerts Antiviral Activity against Zika and Dengue Virus at Safe Doses for Adult Zebrafish
- Authors
- Tamkutė, L., Haddad, J.G., Diotel, N., Desprès, P., Venskutonis, P.R., El Kalamouni, C.
- ID
- ZDB-PUB-220530-21
- Date
- 2022
- Source
- Viruses 14(5): (Journal)
- Registered Authors
- Keywords
- agri-food byproduct, antiviral activity, cranberry, dengue virus, phytocompound, zebrafish, zika virus
- MeSH Terms
-
- Animals
- Antiviral Agents/pharmacology
- Antiviral Agents/therapeutic use
- Dengue Virus*
- Fruit
- Plant Extracts/pharmacology
- Plant Extracts/therapeutic use
- Polyphenols/pharmacology
- Vaccinium macrocarpon*
- Zebrafish
- Zika Virus*
- Zika Virus Infection*
- PubMed
- 35632841 Full text @ Viruses
Citation
Tamkutė, L., Haddad, J.G., Diotel, N., Desprès, P., Venskutonis, P.R., El Kalamouni, C. (2022) Cranberry Pomace Extract Exerts Antiviral Activity against Zika and Dengue Virus at Safe Doses for Adult Zebrafish. Viruses. 14(5).
Abstract
Mosquito-borne dengue virus (DENV) and zika virus (ZIKV) infections constitute a global health emergency. Antivirals directly targeting the virus infectious cycle are still needed to prevent dengue hemorrhagic fever and congenital zika syndrome. In the present study, we demonstrated that Cranberry Pomace (CP) extract, a polyphenol-rich agrifood byproduct recovered following cranberry juice extraction, blocks DENV and ZIKV infection in human Huh7.5 and A549 cell lines, respectively, in non-cytotoxic concentrations. Our virological assays identified CP extract as a potential inhibitor of virus entry into the host-cell by acting directly on viral particles, thus preventing their attachment to the cell surface. At effective antiviral doses, CP extract proved safe and tolerable in a zebrafish model. In conclusion, polyphenol-rich agrifood byproducts such as berry extracts are a promising source of safe and naturally derived nutraceutical antivirals that target medically important pathogens.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping