PUBLICATION
Maintenance of quiescent oocytes by noradrenergic signals
- Authors
- Kim, J., Hyun, M., Hibi, M., You, Y.J.
- ID
- ZDB-PUB-211129-74
- Date
- 2021
- Source
- Nature communications 12: 6925 (Journal)
- Registered Authors
- Hibi, Masahiko
- Keywords
- none
- MeSH Terms
-
- Animals
- Caenorhabditis/genetics
- Caenorhabditis elegans/genetics
- Cell Division/drug effects*
- Drosophila melanogaster/genetics
- Evolution, Molecular
- Female
- Food
- Norepinephrine/pharmacology*
- Nutrients
- Octopamine/pharmacology
- Oocytes/cytology
- Oocytes/drug effects*
- Oogenesis
- Ovarian Follicle/cytology
- Ovarian Follicle/physiology
- Starvation
- Zebrafish/genetics
- PubMed
- 34836956 Full text @ Nat. Commun.
Citation
Kim, J., Hyun, M., Hibi, M., You, Y.J. (2021) Maintenance of quiescent oocytes by noradrenergic signals. Nature communications. 12:6925.
Abstract
All females adopt an evolutionary conserved reproduction strategy; under unfavorable conditions such as scarcity of food or mates, oocytes remain quiescent. However, the signals to maintain oocyte quiescence are largely unknown. Here, we report that in four different species - Caenorhabditis elegans, Caenorhabditis remanei, Drosophila melanogaster, and Danio rerio - octopamine and norepinephrine play an essential role in maintaining oocyte quiescence. In the absence of mates, the oocytes of Caenorhabditis mutants lacking octopamine signaling fail to remain quiescent, but continue to divide and become polyploid. Upon starvation, the egg chambers of D. melanogaster mutants lacking octopamine signaling fail to remain at the previtellogenic stage, but grow to full-grown egg chambers. Upon starvation, D. rerio lacking norepinephrine fails to maintain a quiescent primordial follicle and activates an excessive number of primordial follicles. Our study reveals an evolutionarily conserved function of the noradrenergic signal in maintaining quiescent oocytes.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping