PUBLICATION
The Antitumor Activity and Mechanism of a Natural Diterpenoid From Casearia graveolens
- Authors
- Li, Y., Ma, J., Song, Z., Zhao, Y., Zhang, H., Li, Y., Xu, J., Guo, Y.
- ID
- ZDB-PUB-210714-9
- Date
- 2021
- Source
- Frontiers in oncology 11: 688195 (Journal)
- Registered Authors
- Keywords
- FAK-MMPs, antiangiogenesis inhibitors, apoptosis, cell cycle, cytotoxic activity, zebrafish xenograft model
- MeSH Terms
- none
- PubMed
- 34249737 Full text @ Front Oncol
Citation
Li, Y., Ma, J., Song, Z., Zhao, Y., Zhang, H., Li, Y., Xu, J., Guo, Y. (2021) The Antitumor Activity and Mechanism of a Natural Diterpenoid From Casearia graveolens. Frontiers in oncology. 11:688195.
Abstract
Casearlucin A, a diterpenoid obtained from Casearia graveolens, has been reported to possess strong cytotoxic activity. However, the in vivo anti-tumor effects and the action mechanism of casearlucin A remain poorly understood. Our study revealed that casearlucin A arrested cell cycle at G0/G1 stage and induced cell apoptosis in cell level. Additionally, casearlucin A inhibited HepG2 cell migration via regulating a few of metastasis-related proteins. Furthermore, it inhibited tumor angiogenesis in zebrafish in vivo. More importantly, casearlucin A significantly inhibited cell proliferation and migration in an in vivo zebrafish xenograft model. Collectively, these results are valuable for the further development and application of casearlucin A as an anticancer agent.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping