ZFIN ID: ZDB-PUB-210421-6
Adaptive cell invasion maintains lateral line organ homeostasis in response to environmental changes
Peloggia, J., Münch, D., Meneses-Giles, P., Romero-Carvajal, A., Lush, M.E., Lawson, N.D., McClain, M., Pan, Y.A., Piotrowski, T.
Date: 2021
Source: Developmental Cell   56(9): 1296-1312.e7 (Journal)
Registered Authors: Lawson, Nathan, Lush, Mark E., Pan, Y. Albert, Piotrowski, Tatjana
Keywords: acclimation, basal keratinocytes, cell migration, invasion, ion homeostasis, ionocytes, lateral line, neuromasts, sensory hair cells, zebrafish
Microarrays: GEO:GSE168695
MeSH Terms:
  • Adaptation, Physiological*
  • Animals
  • Biomarkers/metabolism
  • Cell Count
  • Cell Movement*
  • Environment*
  • Forkhead Transcription Factors/metabolism
  • Gills/cytology
  • Hair Cells, Auditory/cytology
  • Homeostasis*
  • Hydrogen-Ion Concentration
  • Imaging, Three-Dimensional
  • Lateral Line System/cytology*
  • Receptors, Notch/metabolism
  • Salinity
  • Signal Transduction
  • Skin/cytology
  • Zebrafish/physiology*
  • Zebrafish Proteins/metabolism
PubMed: 33878346 Full text @ Dev. Cell
Mammalian inner ear and fish lateral line sensory hair cells (HCs) detect fluid motion to transduce environmental signals. Actively maintained ionic homeostasis of the mammalian inner ear endolymph is essential for HC function. In contrast, fish lateral line HCs are exposed to the fluctuating ionic composition of the aqueous environment. Using lineage labeling, in vivo time-lapse imaging and scRNA-seq, we discovered highly motile skin-derived cells that invade mature mechanosensory organs of the zebrafish lateral line and differentiate into Neuromast-associated (Nm) ionocytes. This invasion is adaptive as it is triggered by environmental fluctuations. Our discovery of Nm ionocytes challenges the notion of an entirely placodally derived lateral line and identifies Nm ionocytes as likely regulators of HC function possibly by modulating the ionic microenvironment. Nm ionocytes provide an experimentally accessible in vivo system to study cell invasion and migration, as well as the physiological adaptation of vertebrate organs to changing environmental conditions.