PUBLICATION
Spontaneous and evoked activity patterns diverge over development
- Authors
- Avitan, L., Pujic, Z., Mölter, J., Zhu, S., Sun, B., Goodhill, G.J.
- ID
- ZDB-PUB-210420-10
- Date
- 2021
- Source
- eLIFE 10: (Journal)
- Registered Authors
- Keywords
- neuroscience, zebrafish
- MeSH Terms
-
- Animals
- Bayes Theorem
- Calcium/physiology
- Evoked Potentials, Visual*
- Neurons/physiology*
- Zebrafish/growth & development
- Zebrafish/physiology*
- PubMed
- 33871351 Full text @ Elife
Citation
Avitan, L., Pujic, Z., Mölter, J., Zhu, S., Sun, B., Goodhill, G.J. (2021) Spontaneous and evoked activity patterns diverge over development. eLIFE. 10:.
Abstract
The immature brain is highly spontaneously active. Over development this activity must be integrated with emerging patterns of stimulus-evoked activity, but little is known about how this occurs. Here we investigated this question by recording spontaneous and evoked neural activity in the larval zebrafish tectum from 4 to 15 days post fertilisation. Correlations within spontaneous and evoked activity epochs were comparable over development, and their neural assemblies properties refined in similar ways. However both the similarity between evoked and spontaneous assemblies, and also the geometric distance between spontaneous and evoked patterns, decreased over development. At all stages of development evoked activity was of higher dimension than spontaneous activity. Thus spontaneous and evoked activity do not converge over development in this system, and these results do not support the hypothesis that spontaneous activity evolves to form a Bayesian prior for evoked activity.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping