PUBLICATION
Developmental and Neurotoxicity of Acrylamide to Zebrafish
- Authors
- Park, J.S., Samanta, P., Lee, S., Lee, J., Cho, J.W., Chun, H.S., Yoon, S., Kim, W.K.
- ID
- ZDB-PUB-210407-39
- Date
- 2021
- Source
- International Journal of Molecular Sciences 22(7): (Journal)
- Registered Authors
- Keywords
- acrylamide, developmental toxicity, disease models, neurodevelopmental disorders, neurotoxicity, zebrafish
- MeSH Terms
-
- Disease Models, Animal
- Zebrafish/growth & development*
- Zebrafish/physiology
- Neurotoxicity Syndromes/etiology
- Neurotoxicity Syndromes/physiopathology*
- Animals, Genetically Modified
- Acrylamide/pharmacology
- Acrylamide/toxicity*
- Embryonic Development/drug effects
- Air Sacs/pathology
- Scoliosis/etiology
- Swimming
- Animals
- Embryo, Nonmammalian/drug effects*
- Embryo, Nonmammalian/physiopathology
- PubMed
- 33805345 Full text @ Int. J. Mol. Sci.
Citation
Park, J.S., Samanta, P., Lee, S., Lee, J., Cho, J.W., Chun, H.S., Yoon, S., Kim, W.K. (2021) Developmental and Neurotoxicity of Acrylamide to Zebrafish. International Journal of Molecular Sciences. 22(7):.
Abstract
Acrylamide is a commonly used industrial chemical that is known to be neurotoxic to mammals. However, its developmental toxicity is rarely assessed in mammalian models because of the cost and complexity involved. We used zebrafish to assess the neurotoxicity, developmental and behavioral toxicity of acrylamide. At 6 h post fertilization, zebrafish embryos were exposed to four concentrations of acrylamide (10, 30, 100, or 300 mg/L) in a medium for 114 h. Acrylamide caused developmental toxicity characterized by yolk retention, scoliosis, swim bladder deficiency, and curvature of the body. Acrylamide also impaired locomotor activity, which was measured as swimming speed and distance traveled. In addition, treatment with 100 mg/L acrylamide shortened the width of the brain and spinal cord, indicating neuronal toxicity. In summary, acrylamide induces developmental toxicity and neurotoxicity in zebrafish. This can be used to study acrylamide neurotoxicity in a rapid and cost-efficient manner.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping