PUBLICATION
The Bdkrb2 gene family provides a novel view of viviparity adaptation in Sebastes schlegelii
- Authors
- Niu, J., Song, W., Li, R., Yu, H., Guan, J., Qi, J., He, Y.
- ID
- ZDB-PUB-210319-10
- Date
- 2021
- Source
- BMC ecology and evolution 21: 44 (Journal)
- Registered Authors
- He, Yan
- Keywords
- Adaptation, Bdkrb2, Ovarian wall, Vasodilatation, Viviparity
- MeSH Terms
-
- Animals
- Female
- Gene Expression Profiling
- Ovary
- Perciformes*/genetics
- Phylogeny
- Zebrafish*
- PubMed
- 33731008 Full text @ BMC Ecol Evol
Citation
Niu, J., Song, W., Li, R., Yu, H., Guan, J., Qi, J., He, Y. (2021) The Bdkrb2 gene family provides a novel view of viviparity adaptation in Sebastes schlegelii. BMC ecology and evolution. 21:44.
Abstract
Background Black rockfish (Sebastes schlegelii) is a viviparous teleost. We proposed that the rockfish ovarian wall had a similar function to the uterus of mammals previously. In the present study, the well-developed vascular system was observed in the ovarian wall and the exterior surface of the egg membrane. In gestation, adaptation of the ovary vasculature to the rising needs of the embryos occurs through both vasodilation and neovascularization. Bdkrb2, encoding a receptor for bradykinin, plays a critical role in the control of vasodilatation by regulating nitric oxide production.
Results Eight Bdkrb2 genes were identified in the black rockfish genome. These genes were located on chromosome 14, which are arranged in a tandem array, forming a gene cluster spanning 50 kb. Protein structure prediction, phylogenetic analysis, and transcriptome analysis showed that eight Bdkrb2 genes evolved two kinds of protein structure and three types of tissue expression pattern. Overexpression of two Bdkrb2 genes in zebrafish indicated a role of them in blood vessel formation or remodeling, which is an important procedure for the viviparous rockfish getting prepared for fertilization and embryos implantation.
Conclusions Our study characterizes eight Bdrkb2 genes in the black rockfish, which may contribute to preparation for fertilization and embryo implantation. This research provides a novel view of viviparity adaptation and lays the groundwork for future research into vascular regulation of ovarian tissue in the breeding cycle in black rockfish.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping