PUBLICATION
Cellular Mechanisms Participating in Brain Repair of Adult Zebrafish and Mammals after Injury
- Authors
- Ghaddar, B., Lübke, L., Couret, D., Rastegar, S., Diotel, N.
- ID
- ZDB-PUB-210307-25
- Date
- 2021
- Source
- Cells 10(2): (Review)
- Registered Authors
- Diotel, Nicolas, Lübke, Luisa, Rastegar, Sepand
- Keywords
- adult neurogenesis, brain injury, mice, neural stem cell, regeneration, stroke, zebrafish
- MeSH Terms
-
- Brain/metabolism*
- Neurons/physiology
- Neurogenesis/physiology*
- Cell Differentiation/physiology*
- Neural Stem Cells/cytology*
- Animals
- Nerve Regeneration/physiology
- Zebrafish/physiology
- PubMed
- 33672842 Full text @ Cells
Citation
Ghaddar, B., Lübke, L., Couret, D., Rastegar, S., Diotel, N. (2021) Cellular Mechanisms Participating in Brain Repair of Adult Zebrafish and Mammals after Injury. Cells. 10(2):.
Abstract
Adult neurogenesis is an evolutionary conserved process occurring in all vertebrates. However, striking differences are observed between the taxa, considering the number of neurogenic niches, the neural stem cell (NSC) identity, and brain plasticity under constitutive and injury-induced conditions. Zebrafish has become a popular model for the investigation of the molecular and cellular mechanisms involved in adult neurogenesis. Compared to mammals, the adult zebrafish displays a high number of neurogenic niches distributed throughout the brain. Furthermore, it exhibits a strong regenerative capacity without scar formation or any obvious disabilities. In this review, we will first discuss the similarities and differences regarding (i) the distribution of neurogenic niches in the brain of adult zebrafish and mammals (mainly mouse) and (ii) the nature of the neural stem cells within the main telencephalic niches. In the second part, we will describe the cascade of cellular events occurring after telencephalic injury in zebrafish and mouse. Our study clearly shows that most early events happening right after the brain injury are shared between zebrafish and mouse including cell death, microglia, and oligodendrocyte recruitment, as well as injury-induced neurogenesis. In mammals, one of the consequences following an injury is the formation of a glial scar that is persistent. This is not the case in zebrafish, which may be one of the main reasons that zebrafish display a higher regenerative capacity.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping