PUBLICATION
Evaluation of the Anticancer Activities of Novel Transition Metal Complexes with Berenil and Nitroimidazole
- Authors
- Czarnomysy, R., Radomska, D., Muszy?ska, A., Hermanowicz, J.M., Prokop, I., Bielawska, A., Bielawski, K.
- ID
- ZDB-PUB-210305-14
- Date
- 2020
- Source
- Molecules 25(12): (Journal)
- Registered Authors
- Keywords
- anticancer compounds, breast cancer, multi-factorial compounds, nitroimidazole, transition metal complexes
- MeSH Terms
-
- Organometallic Compounds/pharmacology*
- Humans
- Antineoplastic Agents/pharmacology*
- Gold/pharmacology
- Cisplatin/pharmacology
- Zebrafish
- Coordination Complexes/chemical synthesis
- Coordination Complexes/chemistry
- Coordination Complexes/pharmacology*
- Cell Line, Tumor
- Diminazene/analogs & derivatives*
- Diminazene/chemistry
- DNA/drug effects
- DNA/metabolism
- Female
- Animals
- Palladium/pharmacology
- Membrane Potential, Mitochondrial/drug effects
- Mitochondria/drug effects
- Mitochondria/metabolism
- DNA Topoisomerases, Type II/metabolism
- Transition Elements/chemistry
- Platinum/pharmacology
- Autophagosomes/drug effects*
- Nitroimidazoles/chemistry*
- Apoptosis/drug effects
- Apoptosis/genetics
- Breast Neoplasms/drug therapy*
- Xenograft Model Antitumor Assays
- Cell Survival/drug effects
- PubMed
- 32575817 Full text @ Molecules
Citation
Czarnomysy, R., Radomska, D., Muszy?ska, A., Hermanowicz, J.M., Prokop, I., Bielawska, A., Bielawski, K. (2020) Evaluation of the Anticancer Activities of Novel Transition Metal Complexes with Berenil and Nitroimidazole. Molecules. 25(12):.
Abstract
Novel transition metal complexes (Au, Pd, Pt) with berenil and 2-(1-methyl-5-nitroimidazol-2-yl)ethanol were obtained through two-step synthesis. The cytotoxicity assay against MCF-7 and MDA-MB-231 breast cancer cells revealed that novel platinum and palladium complexes cause a reduction on the viability of MCF-7 and MDA-MB-231 breast cancer cells to a greater extent than cisplatin. The complexes showed lower cytotoxicity on normal MCF-10A human breast epithelial cells than on tumor cells. Furthermore, we observed that these complexes selectively concentrate in tumor cell mitochondria due to the characteristic for these cells increased membrane potential that may explain their increased proapoptotic activity. The activity of the synthesized compounds against topoisomerase type IIα and their increased impact on DNA defragmentation also were documented. The novel complexes also induced autophagosome changes and inhibited tumor growth in xenograft models (established using breast cancer cells).
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping