Zebrafish Models to Study Inflammasome-Mediated Regulation of Hematopoiesis
- Rodríguez-Ruiz, L., Lozano-Gil, J.M., Lachaud, C., Mesa-Del-Castillo, P., Cayuela, M.L., García-Moreno, D., Pérez-Oliva, A.B., Mulero, V.
- Trends in immunology 41(12): 1116-1127 (Review)
- Registered Authors
- Mulero, Victor
- Caspase-1, GATA1, anemia, hematopoiesis, inflammasome, neutrophilia
- MeSH Terms
- Models, Animal*
- Zebrafish Proteins/genetics
- Zebrafish Proteins/immunology
- 33162327 Full text @ Trends Immunol.
Rodríguez-Ruiz, L., Lozano-Gil, J.M., Lachaud, C., Mesa-Del-Castillo, P., Cayuela, M.L., García-Moreno, D., Pérez-Oliva, A.B., Mulero, V. (2020) Zebrafish Models to Study Inflammasome-Mediated Regulation of Hematopoiesis. Trends in immunology. 41(12):1116-1127.
Hematopoiesis is a complex process through which immature bone marrow precursor cells mature into all types of blood cells. Although the association of hematopoietic lineage bias (including anemia and neutrophilia) with chronic inflammatory diseases has long been appreciated, the causes involved are obscure. Recently, cytosolic multiprotein inflammasome complexes were shown to activate inflammatory and immune responses, and directly regulate hematopoiesis in zebrafish models; this was deemed to occur via cleavage and inactivation of the master erythroid transcription factor GATA1. Herein summarized are the zebrafish models that are currently available to study this unappreciated role of inflammasome-mediated regulation of hematopoiesis. Novel putative therapeutic strategies, for the treatment of hematopoietic alterations associated with chronic inflammatory diseases in humans, are also proposed.
Genes / Markers
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Engineered Foreign Genes