PUBLICATION
The slc4a2b gene is required for hair cell development in zebrafish
- Authors
- Qian, F., Wang, X., Yin, Z., Xie, G., Yuan, H., Liu, D., Chai, R.
- ID
- ZDB-PUB-201015-8
- Date
- 2020
- Source
- Aging 12(19): 18804-18821 (Journal)
- Registered Authors
- Liu, Dong, Wang, Xin, Yin, Zhenhua
- Keywords
- apoptosis, hair cell, neuromast, slc4a2b gene, zebrafish
- MeSH Terms
- none
- PubMed
- 33044947 Full text @ Aging (Albany NY)
Citation
Qian, F., Wang, X., Yin, Z., Xie, G., Yuan, H., Liu, D., Chai, R. (2020) The slc4a2b gene is required for hair cell development in zebrafish. Aging. 12(19):18804-18821.
Abstract
Hair cells (HCs) function as important sensory receptors that can detect movement in their immediate environment. HCs in the inner ear can sense acoustic signals, while in aquatic vertebrates HCs can also detect movements, vibrations, and pressure gradients in the surrounding water. Many genes are responsible for the development of HCs, and developmental defects in HCs can lead to hearing loss and other sensory dysfunctions. Here, we found that the solute carrier family 4, member 2b (slc4a2b) gene, which is a member of the anion-exchange family, is expressed in the otic vesicles and lateral line neuromasts in developing zebrafish embryos. An in silico analysis showed that the slc4a2b is evolutionarily conserved, and we found that loss of function of slc4a2b resulted in a decreased number of HCs in zebrafish neuromasts due to increased HC apoptosis. Taken together, we conclude that slc4a2b plays a critical role in the development of HCs in zebrafish.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping