ZFIN ID: ZDB-PUB-201002-22
Zebrafish as a model to study autophagy and its role in skeletal development and disease
Moss, J.J., Hammond, C.L., Lane, J.D.
Date: 2020
Source: Histochemistry and cell biology   154(5): 549-564 (Review)
Registered Authors: Hammond, Chrissy
Keywords: Autophagy, Bone, Development, Tools, Zebrafish
MeSH Terms:
  • Animals
  • Autophagy*
  • Disease Models, Animal*
  • Homeostasis
  • Muscle, Skeletal/metabolism*
  • Muscular Diseases/metabolism*
  • Muscular Diseases/pathology
  • Zebrafish*
PubMed: 32915267 Full text @ Histochem. Cell Biol.
In the last twenty years, research using zebrafish as a model organism has increased immensely. With the many advantages that zebrafish offer such as high fecundity, optical transparency, ex vivo development, and genetic tractability, they are well suited to studying developmental processes and the effect of genetic mutations. More recently, zebrafish models have been used to study autophagy. This important protein degradation pathway is needed for cell and tissue homeostasis in a variety of contexts. Correspondingly, its dysregulation has been implicated in multiple diseases including skeletal disorders. In this review, we explore how zebrafish are being used to study autophagy in the context of skeletal development and disease, and the ways these areas are intersecting to help identify potential therapeutic targets for skeletal disorders.