ZFIN ID: ZDB-PERS-020807-3
Hammond, Chrissy
Email: chrissy.hammond@bristol.ac.uk
Affiliation: Hammond Lab
Address: Departments of Biochemistry / Physiology and Pharmacology Medical Sciences, University of Bristol University Walk Clifton, BS8 1TD United Kingdom
Country: United Kingdom
Phone: +44 0117 33 12228

I started working with zebrafish during my PhD in London in Simon Hughes group, looking at muscle development and the origins of the vertebrate. After a brief postdoc working on chick bone I found my way back to working with fish on an EMBO fellowship at the Hubrecht Institute in the Netherlands identifying mutants that affected skeletal development. I started my own group at the University of Bristol with funding from Arthritis Research UK back in December 2010 studying cartilage and bone homeostasis in development and disease and since then I've been slowly convincing anyone and everyone in Bristol who will listen that zebrafish are awesome and they should work on them.

Godivier, J., Lawrence, E.A., Wang, M., Hammond, C.L., Nowlan, N.C. (2022) Growth orientations, rather than heterogeneous growth rates, dominate jaw joint morphogenesis in the larval zebrafish. Journal of anatomy. 241(2):358-371
Bergen, D.J.M., Tong, Q., Shukla, A., Newham, E., Zethof, J., Lundberg, M., Ryan, R., Youlten, S.E., Frysz, M., Croucher, P.I., Flik, G., Richardson, R.J., Kemp, J.P., Hammond, C.L., Metz, J.R. (2022) Regenerating zebrafish scales express a subset of evolutionary conserved genes involved in human skeletal disease. BMC Biology. 20:21
Kague, E., Turci, F., Newman, E., Yang, Y., Brown, K.R., Aglan, M.S., Otaify, G.A., Temtamy, S.A., Ruiz-Perez, V.L., Cross, S., Royall, C.P., Witten, P.E., Hammond, C.L. (2021) 3D assessment of intervertebral disc degeneration in zebrafish identifies changes in bone density that prime disc disease. Bone research. 9:39
Stevenson, N.L., Bergen, D.J.M., Lu, Y., Prada-Sanchez, M.E., Kadler, K.E., Hammond, C.L., Stephens, D.J. (2021) Giantin is required for intracellular N-terminal processing of type I procollagen. The Journal of cell biology. 220(6)
Tobias, J.H., Duncan, E.L., Kague, E., Hammond, C.L., Gregson, C.L., Bassett, D., Williams, G.R., Min, J.L., Gaunt, T.R., Karasik, D., Ohlsson, C., Rivadeneira, F., Edwards, J.R., Hannan, F.M., Kemp, J.P., Gilbert, S.J., Alonso, N., Hassan, N., Compston, J.E., Ralston, S.H. (2021) Opportunities and Challenges in Functional Genomics Research in Osteoporosis: Report From a Workshop Held by the Causes Working Group of the Osteoporosis and Bone Research Academy of the Royal Osteoporosis Society on October 5th 2020. Frontiers in endocrinology. 11:630875
McDonald, G.L.K., Wang, M., Hammond, C.L., Bergen, D.J.M. (2021) Pharmacological Manipulation of Early Zebrafish Skeletal Development Shows an Important Role for Smad9 in Control of Skeletal Progenitor Populations. Biomolecules. 11(2):
López-Cuevas, P., Deane, L., Yang, Y., Hammond, C.L., Kague, E. (2021) Transformed notochordal cells trigger chronic wounds destabilizing the vertebral column and bone homeostasis. Disease models & mechanisms. 14(3):
McGowan, L.M., Kague, E., Vorster, A., Newham, E., Cross, S., Hammond, C.L. (2021) Wnt16 Elicits a Protective Effect Against Fractures and Supports Bone Repair in Zebrafish. JBMR plus. 5:e10461
Lawrence, E.A., Aggleton, J., van Loon, J., Godivier, J., Harniman, R., Pei, J., Nowlan, N., Hammond, C. (2021) Exposure to hypergravity during zebrafish development alters cartilage material properties and strain distribution. Bone & joint research. 10:137-148
Dietrich, K., Fiedler, I., Kurzyukova, A., López-Delgado, A.C., McGowan, L., Geurtzen, K., Hammond, C., Busse, B., Knopf, F. (2021) Skeletal biology and disease modeling in zebrafish. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 36(3):436-458
da Silva, R.S., Dantas, V.L.G., Alves, L.U., Batissoco, A.C., Oiticica, J., Lawrence, E.A., Kawafi, A., Yang, Y., Nicastro, F.S., Novaes, B.C., Hammond, C., Kague, E., Netto, R.C.M. (2020) NCOA3 identified as a new candidate to explain autosomal dominant progressive hearing loss. Human molecular genetics. 29(22):3691-3705
Lawrence, E.A., Hammond, C.L., Blain, E.J. (2020) Potential of zebrafish as a model to characterise MicroRNA profiles in mechanically mediated joint degeneration. Histochemistry and cell biology. 154(5):521-531
Moss, J.J., Hammond, C.L., Lane, J.D. (2020) Zebrafish as a model to study autophagy and its role in skeletal development and disease. Histochemistry and cell biology. 154(5):549-564
Newham, E., Kague, E., Aggleton, J.A., Fernee, C., Brown, K.R., Hammond, C.L. (2019) Finite element and deformation analyses predict pattern of bone failure in loaded zebrafish spines. Journal of the Royal Society, Interface. 16:20190430
Gregson, C.L., Bergen, D., Leo, P., Sessions, R.B., Wheeler, L., Hartley, A., Youlten, S., Croucher, P.I., McInerney-Leo, A.M., Fraser, W., Tang, J.C.Y., Anderson, L., Marshall, M., Sergot, L., Paternoster, L., Davey-Smith, G., AOGC Consortium, Brown, M.A., Hammond, C., Kemp, J.P., Tobias, J.H., Duncan, E.L. (2019) A rare mutation in SMAD9 associated with high bone mass identifies the SMAD-dependent BMP signalling pathway as a potential anabolic target for osteoporosis. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 35(1):92-105
Kague, E., Hughes, S.M., A Lawrence, E., Cross, S., Martin-Silverstone, E., Hammond, C.L., Hinits, Y. (2019) Scleraxis genes are required for normal musculoskeletal development and for rib growth and mineralization in zebrafish. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 33(8):9116-9130
Lawrence, E.A., Kague, E., Aggleton, J.A., Harniman, R.L., Roddy, K.A., Hammond, C.L. (2018) The mechanical impact of col11a2 loss on joints; col11a2 mutant zebrafish show changes to joint development and function, which leads to early-onset osteoarthritis.. Philosophical transactions of the Royal Society of London. Series B, Biological sciences. 373(1759)
Stevenson, N.L., Bergen, D.J.M., Xu, A., Wyatt, E., Henry, F., McCaughey, J., Vuolo, L., Hammond, C.L., Stephens, D.J. (2018) Regulator of calcineurin-2 is a centriolar protein with a role in cilia length control. Journal of Cell Science. 131(9)
Kague, E., Witten, P.E., Soenens, M., Campos, C.L., Lubiana, T., Fisher, S., Hammond, C., Brown, K.R., Passos-Bueno, M.R., Huysseune, A. (2018) Zebrafish sp7 mutants show tooth cycling independent of attachment, eruption and poor differentiation of teeth. Developmental Biology. 435(2):176-184
Stevenson, N.L., Bergen, D.J.M., Skinner, R.E.H., Kague, E., Martin-Silverstone, E., Robson Brown, K.A., Hammond, C.L., Stephens, D.J. (2017) Giantin knockout models reveal a feedback loop between Golgi function and glycosyltransferase expression. Journal of Cell Science. 130(24):4132-4143
Bergen, D.J.M., Stevenson, N.L., Skinner, R.E.H., Stephens, D.J., Hammond, C.L. (2017) The Golgi matrix protein giantin is required for normal cilia function in zebrafish. Biology Open. 6(8):1180-1189
Brunt, L.H., Begg, K., Kague, E., Cross, S., Hammond, C.L. (2017) Wnt signalling controls the response to mechanical loading during Zebrafish joint development. Development (Cambridge, England). 144(15):2798-2809
Brunt, L.H., Roddy, K.A., Rayfield, E.J., Hammond, C.L. (2016) Building Finite Element Models to Investigate Zebrafish Jaw Biomechanics. Journal of visualized experiments : JoVE. (118)
Brunt, L.H., Skinner, R.E., Roddy, K.A., Araujo, N.M., Rayfield, E.J., Hammond, C.L. (2016) Differential effects of altered patterns of movement and strain on joint cell behaviour and skeletal morphogenesis. Osteoarthritis and Cartilage. 24(11):1940-1950
Pipalia, T.G., Koth, J., Roy, S.D., Hammond, C.L., Kawakami, K., Hughes, S.M. (2016) Cellular dynamics of regeneration reveals role of two distinct Pax7 stem cell populations in larval zebrafish muscle repair. Disease models & mechanisms. 9(6):671-84
Brunt, L.H., Norton, J.L., Bright, J.A., Rayfield, E.J., Hammond, C.L. (2015) Finite element modelling predicts changes in joint shape and cell behaviour due to loss of muscle strain in jaw development. Journal of biomechanics. 48(12):3112-22
Zancan, I., Bellesso, S., Costa, R., Salvalaio, M., Stroppiano, M., Hammond, C., Argenton, F., Filocamo, M., Moro, E. (2015) Glucocerebrosidase deficiency in zebrafish affects primary bone ossification through increased oxidative stress and reduced Wnt/β-catenin signaling. Human molecular genetics. 24(5):1280-94
Hayes, A.J., Reynolds, S., Nowell, M.A., Meakin, L.B., Habicher, J., Ledin, J., Bashford, A., Caterson, B., and Hammond, C.L. (2013) Spinal Deformity in Aged Zebrafish Is Accompanied by Degenerative Changes to Their Vertebrae that Resemble Osteoarthritis. PLoS One. 8(9):e75787
Hayes, A.J., Mitchell, R.E., Bashford, A., Reynolds, S., Caterson, B., and Hammond, C.L. (2013) Expression of glycosaminoglycan epitopes during zebrafish skeletogenesis. Developmental dynamics : an official publication of the American Association of Anatomists. 242(6):778-89
Mitchell, R.E., Huitema, L.F., Skinner, R.H., Brunt, L.H., Severn, C., Schulte-Merker, S., and Hammond, C.L. (2013) New tools for studying osteoarthritis genetics in zebrafish. Osteoarthritis and Cartilage. 21(2):269-278
Huitema, L.F., Apschner, A., Logister, I., Spoorendonk, K.M., Bussmann, J., Hammond, C.L., and Schulte-Merker, S. (2012) Entpd5 is essential for skeletal mineralization and regulates phosphate homeostasis in zebrafish. Proceedings of the National Academy of Sciences of the United States of America. 109(52):21372-21377
Hammond, C.L., and Moro, E. (2012) Using transgenic reporters to visualize bone and cartilage signaling during development in vivo. Frontiers in Experimental Endocrinology. 3:91
Knopf, F., Hammond, C., Chekuru, A., Kurth, T., Hans, S., Weber, C.W., Mahatma, G., Fisher, S., Brand, M., Schulte-Merker, S., and Weidinger, G. (2011) Bone Regenerates via Dedifferentiation of Osteoblasts in the Zebrafish Fin. Developmental Cell. 20(5):713-724
Spoorendonk, K. M., Hammond, C. L. , Huitema, L. F. A., Vanoevelen, J., Schulte-Merker, S. (2010) Zebrafish as a unique model system in bone research: the power of genetics and in vivo imaging. Zeitschrift fur angewandte Ichthyologie = Journal of applied ichthyology. 26(2):219-224
Hammond, C.L., Hinits, Y., Osborn, D.P., Minchin, J.E., Tettamanti, G., and Hughes, S.M. (2007) Signals and myogenic regulatory factors restrict pax3 and pax7 expression to dermomyotome-like tissue in zebrafish. Developmental Biology. 302(2):504-521
Groves, J.A., Hammond, C.L., and Hughes, S.M. (2005) Fgf8 drives myogenic progression of a novel lateral fast muscle fibre population in zebrafish. Development (Cambridge, England). 132(19):4211-4222

Two populations of endochondral osteoblasts with differential sensitivity
to Hedgehog signalling. Hammond CL, Schulte-Merker S. Development. 2009
Dec;136(23):3991-4000.PMID: 19906866

Generality of vertebrate developmental patterns: evidence for a
dermomyotome in fish. Devoto SH, Stoiber W, Hammond CL, Steinbacher P,
Haslett JR, Barresi MJ, Patterson SE, Adiarte EG, Hughes SM. Evol Dev.
2006 Jan-Feb;8(1):101-10. PMID: 16409387

Meta-analysis of genome-wide association studies confirms a susceptibility
locus for knee osteoarthritis on chromosome 7q22. Evangelou E, Valdes AM,
Kerkhof HJ, Styrkarsdottir U, Zhu Y, Meulenbelt I, Lories RJ, Karassa FB,
Tylzanowski P, Bos SD; arcOGEN Consortium, Akune T, Arden NK, Carr A,
Chapman K, Cupples LA, Dai J, Deloukas P, Doherty M, Doherty S, Engstrom
G, Gonzalez A, Halldorsson BV, Hammond CL, Hart DJ, Helgadottir H, Hofman
A, Ikegawa S, Ingvarsson T, Jiang Q, Jonsson H, Kaprio J, Kawaguchi H,
Kisand K, Kloppenburg M, Kujala UM, Lohmander LS, Loughlin J, Luyten FP,
Mabuchi A, McCaskie A, Nakajima M, Nilsson PM, Nishida N, Ollier WE,
Panoutsopoulou K, van de Putte T, Ralston SH, Rivadeneira F, Saarela J,
Schulte-Merker S, Shi D, Slagboom PE, Sudo A, Tamm A, Tamm A, Thorleifsson
G, Thorsteinsdottir U, Tsezou A, Wallis GA, Wilkinson JM, Yoshimura N,
Zeggini E, Zhai G, Zhang F, Jonsdottir I, Uitterlinden AG, Felson DT, van
Meurs JB, Stefansson K, Ioannidis JP, Spector TD; Translation Research in
Europe Applied Technologies for Osteoarthritis (TreatOA). Ann Rheum Dis.
2010 Nov 10. [Epub ahead of print]PMID: 21068099