PUBLICATION
Multiple convergent hypothalamus-brainstem circuits drive defensive behavior
- Authors
- Lovett-Barron, M., Chen, R., Bradbury, S., Andalman, A.S., Wagle, M., Guo, S., Deisseroth, K.
- ID
- ZDB-PUB-200624-8
- Date
- 2020
- Source
- Nature Neuroscience 23(8): 959-967 (Journal)
- Registered Authors
- Guo, Su, Wagle, Mahendra
- Keywords
- none
- MeSH Terms
-
- Animals
- Behavior, Animal/physiology*
- Brain Stem/physiology*
- Calcium/metabolism
- Hypothalamus/physiology*
- Neural Pathways/physiology
- Neurons/physiology*
- Zebrafish/physiology*
- PubMed
- 32572237 Full text @ Nat. Neurosci.
Citation
Lovett-Barron, M., Chen, R., Bradbury, S., Andalman, A.S., Wagle, M., Guo, S., Deisseroth, K. (2020) Multiple convergent hypothalamus-brainstem circuits drive defensive behavior. Nature Neuroscience. 23(8):959-967.
Abstract
The hypothalamus is composed of many neuropeptidergic cell populations and directs multiple survival behaviors, including defensive responses to threats. However, the relationship between the peptidergic identity of neurons and their roles in behavior remains unclear. Here, we address this issue by studying the function of multiple neuronal populations in the zebrafish hypothalamus during defensive responses to a variety of homeostatic threats. Cellular registration of large-scale neural activity imaging to multiplexed in situ gene expression revealed that neuronal populations encoding behavioral features encompass multiple overlapping sets of neuropeptidergic cell classes. Manipulations of different cell populations showed that multiple sets of peptidergic neurons play similar behavioral roles in this fast-timescale behavior through glutamate co-release and convergent output to spinal-projecting premotor neurons in the brainstem. Our findings demonstrate that homeostatic threats recruit neurons across multiple hypothalamic cell populations, which cooperatively drive robust defensive behaviors.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping