ZFIN Person: Guo, Su

ZFIN ID: ZDB-PERS-980512-2

Guo, Su

Email:	su.guo@ucsf.edu
URL:
Affiliation:	Guo Lab
Address:	Department of Biopharmaceutical Sciences Programs in Biological Sciences, Human Genetics, Pharmaceutical Sciences and Pharmacogenomics Wheeler Center for the Neurobiology of Addiction University of California San Francisco Mission Bay Rock Hall 1550 4th Street San Francisco, CA 94143-2811 USA
Country:	United States
Phone:	415-502-4949 (office), 415-514-2662 (lab)
Fax:	415-502-8177
ORCID ID:

BIOGRAPHY AND RESEARCH INTERESTS

In general, neural development; specifically, development and function of the catecholaminergic (dopamine, noradrenaline and adrenaline) systems.

PUBLICATIONS

Zhao, X., Guo, S. (2023) Antibody Uptake Assay for Tracking Notch/Delta Endocytosis During the Asymmetric Division of Zebrafish Radial Glia Progenitors. Journal of visualized experiments : JoVE. (191):

Chen, Z., Long, H., Guo, J., Wang, Y., He, K., Tao, C., Li, X., Jiang, K., Guo, S., Pi, Y. (2022) Autism-Risk Gene necab2 Regulates Psychomotor and Social Behavior as a Neuronal Modulator of mGluR1 Signaling. Frontiers in molecular neuroscience. 15:901682

Wagle, M., Zarei, M., Lovett-Barron, M., Poston, K.T., Xu, J., Ramey, V., Pollard, K.S., Prober, D.A., Schulkin, J., Deisseroth, K., Guo, S. (2022) Brain-wide perception of the emotional valence of light is regulated by distinct hypothalamic neurons. Molecular psychiatry. 27(9):3777-3793

Zarei, M., Xie, D., Jiang, F., Bagirov, A., Huang, B., Raj, A., Nagarajan, S., Guo, S. (2022) High activity and high functional connectivity are mutually exclusive in resting state zebrafish and human brains. BMC Biology. 20:84

Kim, G.J., Mo, H., Liu, H., Okorie, M., Chen, S., Zheng, J., Li, H., Arkin, M., Huang, B., Guo, S. (2022) In Vivo Dopamine Neuron Imaging-Based Small Molecule Screen Identifies Novel Neuroprotective Compounds and Targets. Frontiers in pharmacology. 13:837756

Martins Fernandes Pereira, K., Calheiros de Carvalho, A., André Moura Veiga, T., Melgoza, A., Bonne Hernández, R., Dos Santos Grecco, S., Uchiyama Nakamura, M., Guo, S. (2022) The psychoactive effects of Bryophyllum pinnatum (Lam.) Oken leaves in young zebrafish. PLoS One. 17:e0264987

Zhao, X., Garcia, J., Royer, L.A., Guo, S. (2022) Colocalization Analysis for Cryosectioned and Immunostained Tissue Samples with or without Label Retention Expansion Microscopy (LR-ExM) by JACoP. Bio-protocol. 12:e4336

Kim, G.J., Melgoza, A., Jiang, F., Guo, S. (2021) The effect of renin-angiotensin-aldosterone system inhibitors on organ-specific ace2 expression in zebrafish and its implications for COVID-19. Scientific Reports. 11:23670

Kim, G.J., Mo, H., Liu, H., Wu, Z., Chen, S., Zheng, J., Zhao, X., Nucum, D., Shortland, J., Peng, L., Elepano, M., Tang, B., Olson, S., Paras, N., Li, H., Renslo, A.R., Arkin, M.R., Huang, B., Lu, B., Sirota, M., Guo, S. (2021) A zebrafish screen reveals Renin-angiotensin system inhibitors as neuroprotective via mitochondrial restoration in dopamine neurons. eLIFE. 10:

Dahlén, A., Zarei, M., Melgoza, A., Wagle, M., Guo, S. (2021) THC-induced behavioral stereotypy in zebrafish as a model of psychosis-like behavior. Scientific Reports. 11:15693

Xu, J., Casanave, R., Guo, S. (2021) Larval zebrafish display dynamic learning of aversive stimuli in a constant visual surrounding. Learning & memory (Cold Spring Harbor, N.Y.). 28:228-238

Zhao, X., Garcia, J.Q., Tong, K., Chen, X., Yang, B., Li, Q., Dai, Z., Shi, X., Seiple, I.B., Huang, B., Guo, S. (2021) Polarized endosome dynamics engage cytoplasmic Par-3 that recruits dynein during asymmetric cell division. Science advances. 7(24)

Lovett-Barron, M., Chen, R., Bradbury, S., Andalman, A.S., Wagle, M., Guo, S., Deisseroth, K. (2020) Multiple convergent hypothalamus-brainstem circuits drive defensive behavior. Nature Neuroscience. 23(8):959-967

Dahlén, A., Wagle, M., Zarei, M., Guo, S. (2019) Heritable natural variation of light/dark preference in an outbred zebrafish population. Journal of neurogenetics. 33(4):199-208

Bruning, J.M., Wang, Y., Oltrabella, F., Tian, B., Kholodar, S.A., Liu, H., Bhattacharya, P., Guo, S., Holton, J.M., Fletterick, R.J., Jacobson, M.P., England, P.M. (2019) Covalent Modification and Regulation of the Nuclear Receptor Nurr1 by a Dopamine Metabolite. Cell chemical biology. 26(5):674-685.e6

Huang, R., Chen, M., Yang, L., Wagle, M., Guo, S., Hu, B. (2017) MicroRNA-133b Negatively Regulates Zebrafish Single Mauthner-Cell Axon Regeneration through Targeting tppp3 in Vivo.. Frontiers in molecular neuroscience. 10:375

Wagle, M., Nguyen, J., Lee, S., Zaitlen, N., Guo, S. (2017) Heritable natural variation of an anxiety-like behavior in larval zebrafish. Journal of neurogenetics. 31(3):138-148

Chandrasekhar, A., Guo, S., Masai, I., Nicolson, T., Wu, C.F. (2017) Zebrafish: from genes and neurons to circuits, behavior and disease. Journal of neurogenetics. 31:59-60

Oltrabella, F., Melgoza, A., Nguyen, B., Guo, S. (2017) Role of the endocannabinoid system in vertebrates: Emphasis on the zebrafish model. Development, growth & differentiation. 59(4):194-210

Tong, K., Wagle, M., Guo, S. (2017) Antibody Uptake Assay in the Embryonic Zebrafish Forebrain to Study Notch Signaling Dynamics in Neural Progenitor Cells In Vivo. Methods in molecular biology (Clifton, N.J.).

Liu, H., Chen, S., Huang, K., Kim, J., Mo, H., Iovine, R., Gendre, J., Pascal, P., Li, Q., Sun, Y., Dong, Z., Arkin, M., Guo, S., Huang, B. (2016) A High-Content Larval Zebrafish Brain Imaging Method for Small Molecule Drug Discovery. PLoS One. 11:e0164645

Bai, Y., Liu, H., Huang, B., Wagle, M., Guo, S. (2016) Identification of environmental stressors and validation of light preference as a measure of anxiety in larval zebrafish. BMC Neuroscience. 17:63

Yu, D., Dong, Z., Gustafson, W.C., Ruiz-González, R., Signor, L., Marzocca, F., Borel, F., Klassen, M.P., Makhijani, K., Royant, A., Jan, Y.N., Weiss, W.A., Guo, S., Shu, X. (2016) Rational design of a monomeric and photostable far-red fluorescent protein for fluorescence imaging in vivo. Protein science : a publication of the Protein Society. 25(2):308-15

McGorty, R., Liu, H., Kamiyama, D., Dong, Z., Guo, S., Huang, B. (2015) Open-top selective plane illumination microscope for conventionally mounted specimens. Optics express. 23:16142-16153

Berberoglu, M.A., Dong, Z., Li, G., Zheng, J., Trejo Martinez, L.d.e.l. .C., Peng, J., Wagle, M., Reichholf, B., Petritsch, C., Li, H., Pleasure, S.J., Guo, S. (2014) Heterogeneously Expressed fezf2 Patterns Gradient Notch Activity in Balancing the Quiescence, Proliferation, and Differentiation of Adult Neural Stem Cells. The Journal of neuroscience : the official journal of the Society for Neuroscience. 34:13911-23

Sun, Y., Dong, Z., Jin, T., Ang, K.H., Huang, M., Haston, K.M., Peng, J., Zhong, T.P., Finkbeiner, S., Weiss, W.A., Arkin, M.R., Jan, L.Y., and Guo, S. (2013) Imaging-based chemical screening reveals activity-dependent neural differentiation of pluripotent stem cells. eLIFE. 2:e00508

Dong, Z., Peng, J., and Guo, S. (2013) Stable Gene Silencing in Zebrafish with Spatiotemporally Targetable RNA Interference. Genetics. 193(4):1065-1071

Yang, N., Dong, Z., and Guo, S. (2012) Fezf2 Regulates Multilineage Neuronal Differentiation through Activating Basic Helix-Loop-Helix and Homeodomain Genes in the Zebrafish Ventral Forebrain. The Journal of neuroscience : the official journal of the Society for Neuroscience. 32(32):10940-10948

Dong, Z., Yang, N., Yeo, S.Y., Chitnis, A., and Guo, S. (2012) Intralineage directional notch signaling regulates self-renewal and differentiation of asymmetrically dividing radial glia. Neuron. 74(1):65-78

Guo, S., Wagle, M., and Mathur, P. (2012) Toward molecular genetic dissection of neural circuits for emotional and motivational behaviors. Developmental Neurobiology. 72(3):358-365

Sun, Y., Dong, Z., Khodabakhsh, H., Chatterjee, S., and Guo, S. (2012) Zebrafish chemical screening reveals the impairment of dopaminergic neuronal survival by cardiac glycosides. PLoS One. 7(4):e35645

Ritter, D.I., Dong, Z., Guo, S., and Chuang, J.H. (2012) Transcriptional enhancers in protein-coding exons of vertebrate developmental genes. PLoS One. 7(5):e35202

Mathur, P., and Guo, S. (2011) Differences of acute versus chronic ethanol exposure on anxiety-like behavioral responses in zebrafish. Behavioural brain research. 219(2):234-239

Chen, L., Zheng, J., Yang, N., Li, H., and Guo, S. (2011) Genomic selection identifies vertebrate transcription factor Fezf2 binding sites and target genes. The Journal of biological chemistry. 286(21):18641-18649

Dong, Z., Wagle, M., and Guo, S. (2011) Time-lapse Live Imaging of Clonally Related Neural Progenitor Cells in the Developing Zebrafish Forebrain. Journal of visualized experiments : JoVE. (50)

Mueller, T., Dong, Z., Berberoglu, M.A., and Guo, S. (2011) The dorsal pallium in Zebrafish, Danio rerio (Cyprinidae, Teleostei). Brain research. 1381:95-105

Mathur, P., Lau, B., and Guo, S. (2011) Conditioned place preference behavior in zebrafish. Nature Protocols. 6(3):338-345

Lau, B.Y., Mathur, P., Gould, G.G., and Guo, S. (2011) Identification of a brain center whose activity discriminates a choice behavior in zebrafish. Proceedings of the National Academy of Sciences of the United States of America. 108(6):2581-2586

Mathur, P., Berberoglu, M.A., and Guo, S. (2011) Preference for ethanol in zebrafish following a single exposure. Behavioural brain research. 217(1):128-133

Wagle, M., Mathur, P., and Guo, S. (2011) Corticotropin-releasing factor critical for zebrafish camouflage behavior is regulated by light and sensitive to ethanol. The Journal of neuroscience : the official journal of the Society for Neuroscience. 31(1):214-224

Mathur, P., and Guo, S. (2010) Use of zebrafish as a model to understand mechanisms of addiction and complex neurobehavioral phenotypes. Neurobiology of disease. 40(1):66-72

Ritter, D.I., Li, Q., Kostka, D., Pollard, K.S., Guo, S., and Chuang, J.H. (2010) The Importance of Being Cis: Evolution of Orthologous Fish and Mammalian Enhancer Activity. Mol. Biol. Evol.. 27(10):2322-2332

Li, Q., Ritter, D., Yang, N., Dong, Z., Li, H., Chuang, J.H., and Guo, S. (2010) A systematic approach to identify functional motifs within vertebrate developmental enhancers. Developmental Biology. 337(2):484-495

Mueller, T., and Guo, S. (2009) The distribution of GAD67-mRNA in the adult zebrafish (teleost) forebrain reveals a prosomeric pattern and suggests previously unidentified homologies to tetrapods. The Journal of comparative neurology. 516(6):553-568

Chen, H., Contreras, X., Yamaguchi, Y., Handa, H., Peterlin, B.M., and Guo, S. (2009) Repression of RNA polymerase II elongation in vivo is critically dependent on the C-terminus of Spt5. PLoS One. 4(9):e6918

Berberoglu, M.A., Dong, Z., Mueller, T., and Guo, S. (2009) fezf2 expression delineates cells with proliferative potential and expressing markers of neural stem cells in the adult zebrafish brain. Gene expression patterns : GEP. 9(6):411-422

Guo, S. (2009) Using zebrafish to assess the impact of drugs on neural development and function. Expert opinion on drug discovery. 4(7):715-726

Peng, J., Wagle, M., Mueller, T., Mathur, P., Lockwood, B.L., Bretaud, S., and Guo, S. (2009) Ethanol-modulated camouflage response screen in zebrafish uncovers a novel role for cAMP and extracellular signal-regulated kinase signaling in behavioral sensitivity to ethanol. The Journal of neuroscience : the official journal of the Society for Neuroscience. 29(26):8408-8418

Barboric, M., Lenasi, T., Chen, H., Johansen, E.B., Guo, S., and Peterlin, B.M. (2009) 7SK snRNP/P-TEFb couples transcription elongation with alternative splicing and is essential for vertebrate development. Proceedings of the National Academy of Sciences of the United States of America. 106(19):7798-7803

Persampieri, J., Ritter, D.I., Lees, D., Lehoczky, J., Li, Q., Guo, S., and Chuang, J.H. (2008) cneViewer: A Database of Conserved Non-coding Elements for Studies of Tissue-Specific Gene Regulation. Bioinformatics (Oxford, England). 24(20):2418-2419

Mueller, T., Wullimann, M.F., and Guo, S. (2008) Early teleostean basal ganglia development visualized by Zebrafish Dlx2a, Lhx6, Lhx7, Tbr2 (eomesa), and GAD67 gene expression. The Journal of comparative neurology. 507(2):1245-1257

Krishnan, K., Salomonis, N., and Guo, S. (2008) Identification of Spt5 target genes in zebrafish development reveals its dual activity in vivo. PLoS One. 3(11):e3621

Bretaud, S., Li, Q., Lockwood, B.L., Kobayashi, K., Lin, E., and Guo, S. (2007) A choice behavior for morphine reveals experience-dependent drug preference and underlying neural substrates in developing larval zebrafish. Neuroscience. 146(3):1109-1116

Jeong, J.Y., Einhorn, Z., Mathur, P., Chen, L., Lee, S., Kawakami, K., and Guo, S. (2007) Patterning the zebrafish diencephalon by the conserved zinc-finger protein Fezl. Development (Cambridge, England). 134(1):127-136

Wang, X., Yang, N., Uno, E., Roeder, R.G., and Guo, S. (2006) A subunit of the mediator complex regulates vertebrate neuronal development. Proceedings of the National Academy of Sciences of the United States of America. 103(46):17284-17289

Lau, B., Bretaud, S., Huang, Y., Lin, E., and Guo, S. (2006) Dissociation of food and opiate preference by a genetic mutation in zebrafish. Genes, brain, and behavior. 5(7):497-505

Jeong, J.Y., Einhorn, Z., Mercurio, S., Lee, S., Lau, B., Mione, M., Wilson, S.W., and Guo, S. (2006) Neurogenin1 is a determinant of zebrafish basal forebrain dopaminergic neurons and is regulated by the conserved zinc finger protein Tof/Fezl. Proceedings of the National Academy of Sciences of the United States of America. 103(13):5143-5148

Giacomini, N.J., Rose, B., Kobayashi, K., and Guo, S. (2006) Antipsychotics produce locomotor impairment in larval zebrafish. Neurotoxicology and teratology. 28(2):245-250

Bretaud, S., Lee, S., and Guo, S. (2004) Sensitivity of zebrafish to environmental toxins implicated in Parkinson's disease. Neurotoxicology and teratology. 26(6):857-864

Guo, S. (2004) Linking genes to brain, behavior and neurological diseases: what can we learn from zebrafish?. Genes, brain, and behavior. 3(2):63-74

Lockwood, B., Bjerke, S., Kobayashi, K., and Guo, S. (2004) Acute effects of alcohol on larval zebrafish: a genetic system for large-scale screening. Pharmacology, biochemistry, and behavior. 77(3):647-654

Rink, E., and Guo, S. (2004) The too few mutant selectively affects subgroups of monoaminergic neurons in the zebrafish forebrain. Neuroscience. 127(1):147-154

Lee, S.A., Shen, E.L., Fiser, A., Sali, A., and Guo, S. (2003) The zebrafish forkhead transcription factor Foxi1 specifies epibranchial placode-derived sensory neurons. Development (Cambridge, England). 130(12):2669-2679

Seo, H. Hong, S.J., Guo, S., Kim, H.S., Kim, C.H., Hwang, D.Y., Isacson, O., Rosenthal, A., and Kim, K.S. (2002) A direct role of the homeodomain proteins Phox2a/2b in noradrenaline neurotransmitter identity determination. Journal of neurochemistry. 80(5):905-916

Gerlai, R., Lahav, M., Guo, S., and Rosenthal, A. (2000) Drinks like a fish: zebra fish (Danio rerio) as a behavior genetic model to study alcohol effects. Pharmacology, biochemistry, and behavior. 67(4):773-782

Guo, S., Yamaguchi, Y., Schilbach, S., Wada, T., Lee, J., Goddard, A., French, D., Handa, H., and Rosenthal, A. (2000) A regulator of transcriptional elongation controls vertebrate neuronal development. Nature. 408(6810):366-369

Guo, S., Brush, J., Teraoka, H., Goddard, A., Wilson, S.W., Mullins, M.C., and Rosenthal, A. (1999) Development of noradrenergic neurons in the zebrafish hindbrain requires BMP, FGF8, and the homeodomain protein Soulless/Phox2a. Neuron. 24:555

Guo, S., Wilson, S.W., Cooke, S., Chitnis, A.B., Driever, W., and Rosenthal, A. (1999) Mutations in the zebrafish unmask shared regulatory pathways controlling the development of catecholaminergic neurons. Developmental Biology. 208:473-487

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