PUBLICATION
Brain aromatase modulates cardiac functions in embryonic zebrafish
- Authors
- Ulhaq, Z.S.
- ID
- ZDB-PUB-191108-23
- Date
- 2019
- Source
- International journal of veterinary science and medicine 7: 31-34 (Journal)
- Registered Authors
- Ulhaq, Zulvikar Syambani
- Keywords
- Brain aromatase, cardiovascular, oestradiol, zebrafish
- MeSH Terms
- none
- PubMed
- 31692872 Full text @ Int J Vet Sci Med
Citation
Ulhaq, Z.S. (2019) Brain aromatase modulates cardiac functions in embryonic zebrafish. International journal of veterinary science and medicine. 7:31-34.
Abstract
Oestradiol (E2) is known as a female reproductive hormone with pleiotropic effects on the cardiovascular system. Local E2 biosynthesis such as in the brain and myocardial cells have important physiological and pathophysiological roles. E2 production is catalysed by aromatase (Aro) enzyme. In teleost, two Aro isoforms are distinctly expressed in the ovary and brain. In this study, the role of brain Aro (AroB) in modulating cardiovascular system is investigated. AroB MO-mediated knockdown decreased ventricular functions. Moreover, embryos injected with AroB MO displays a sign in developing heart failure. All the effects caused by AroB MO were partially reversed by exposure to E2. Taken together, this study demonstrates the role of AroB in modulating normal cardiovascular function in zebrafish embryos.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping