PUBLICATION

Reelin Signaling Controls the Preference for Social Novelty in Zebrafish

Authors
Vecchia, E.D., Donato, V.D., Young, A.M.J., Bene, F.D., Norton, W.H.J.
ID
ZDB-PUB-191015-11
Date
2019
Source
Frontiers in behavioral neuroscience   13: 214 (Journal)
Registered Authors
Keywords
5-HT, Reelin, autism, behavior, neurochemistry, neuroscience, social behavior, zebrafish
MeSH Terms
none
PubMed
31607872 Full text @ Front. Behav. Neurosci.
Citation
Vecchia, E.D., Donato, V.D., Young, A.M.J., Bene, F.D., Norton, W.H.J. (2019) Reelin Signaling Controls the Preference for Social Novelty in Zebrafish. Frontiers in behavioral neuroscience. 13:214.
Abstract
Reelin (Reln) is an extracellular glycoprotein that is important for brain patterning. During development Reln coordinates the radial migration of postmitotic cortical neurons, cerebellar and hippocampal neurons, whereas it promotes dendrite maturation, synaptogenesis, synaptic transmission, plasticity and neurotransmitter release in the postnatal and adult brain. Genetic studies of human patients have demonstrated association between the RELN locus and autism spectrum disorder, schizophrenia, bipolar disorder, and Alzheimer's disease. In this study we have characterized the behavioral phenotype of reelin (reln) mutant zebrafish, as well as two canonical signaling pathway targets DAB adaptor protein 1a (dab1a) and the very low density lipoprotein receptor (vldlr). Zebrafish reln-/- mutants display a selective reduction in preference for social novelty that is not observed in dab1a-/- or vldlr-/- mutant lines. They also exhibit an increase in 5-HT signaling in the hindbrain that parallels but does not underpin the alteration in social preference. These results suggest that zebrafish reln-/- mutants can be used to model some aspects of human diseases in which changes to Reln signaling alter social behavior.
Genes / Markers
Figures
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Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Antibodies
Orthology
Engineered Foreign Genes
Mapping
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