PUBLICATION
White LED Light Exposure Inhibits the Development and Xanthophore Pigmentation of Zebrafish Embryo
- Authors
- Üstündağ, Ü.V., Çalıskan-Ak, E., Ateş, P.S., Ünal, İ., Eğilmezer, G., Yiğitbaşı, T., Ata Alturfan, A., Emekli-Alturfan, E.
- ID
- ZDB-PUB-190729-2
- Date
- 2019
- Source
- Scientific Reports 9: 10810 (Journal)
- Registered Authors
- Ateş, Perihan Seda, Eğilmezer, Gizem, Emekli-Alturfan, Ebru, Üstündağ, Ünsal Veli
- Keywords
- none
- MeSH Terms
-
- Animals
- Arylalkylamine N-Acetyltransferase/metabolism
- Behavior, Animal/physiology
- Behavior, Animal/radiation effects
- Body Size/physiology
- Body Size/radiation effects
- Circadian Rhythm/physiology
- Circadian Rhythm/radiation effects*
- Embryonic Development/physiology
- Embryonic Development/radiation effects*
- Light*
- Melatonin/biosynthesis
- Motor Activity/physiology
- Motor Activity/radiation effects*
- PAX2 Transcription Factor/metabolism
- Photoperiod
- Pigmentation/physiology
- Pigmentation/radiation effects*
- Zebrafish
- Zebrafish Proteins/metabolism
- PubMed
- 31346212 Full text @ Sci. Rep.
Citation
Üstündağ, Ü.V., Çalıskan-Ak, E., Ateş, P.S., Ünal, İ., Eğilmezer, G., Yiğitbaşı, T., Ata Alturfan, A., Emekli-Alturfan, E. (2019) White LED Light Exposure Inhibits the Development and Xanthophore Pigmentation of Zebrafish Embryo. Scientific Reports. 9:10810.
Abstract
Circadian rhythm in all living organisms is disturbed continuously by artificial light sources and artificial lighting has become a hazard for public health. Circadian rhythm of melatonin maintains high levels of melatonin during the night and low levels during the day. N-acetyltransferase (arylalkylamine N-acetyltransferase, AANAT) is one of the four enzymes required for melatonin synthesis and mtnr1ba is a melatonin receptor-encoding mRNA that is expressed widely in the embryonic brain. Pax7 has important roles during neural crest development and especially xanthophore pigmentation. Due to its diurnal nature, zebrafish provide a special opportunity for research on circadian rhythms that are regulated by melatonin. Here in this study, we showed that when compared with the white light control group, white LED light exposure resulted in loss of yellow pigmentation, decreased body length and locomotor activity, oxidant-antioxidant imbalance and decreased expressions of aanat2, mtnr1ba, and pax7 in zebrafish embryos. Histological analysis of this group revealed disorganization of the spaces among photoreceptor cells, decreased total retinal thickness and photoreceptor cell layer thickness compared with the control group. Artificial lighting pollution has the potential to become an important risk factor for different diseases including cancer especially for industrialized countries, therefore, more studies should be performed and necessary regulations should be made regarding this risk factor.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping