PUBLICATION
The Henna pigment Lawsone activates the Aryl Hydrocarbon Receptor and impacts skin homeostasis
- Authors
- Lozza, L., Moura-Alves, P., Domaszewska, T., Lage Crespo, C., Streata, I., Kreuchwig, A., Puyskens, A., Bechtle, M., Klemm, M., Zedler, U., Silviu Ungureanu, B., Guhlich-Bornhof, U., Koehler, A.B., Stäber, M., Mollenkopf, H.J., Hurwitz, R., Furkert, J., Krause, G., Weiner, J., Jacinto, A., Mihai, I., Leite-de-Moraes, M., Siebenhaar, F., Maurer, M., Kaufmann, S.H.E.
- ID
- ZDB-PUB-190729-13
- Date
- 2019
- Source
- Scientific Reports 9: 10878 (Journal)
- Registered Authors
- Keywords
- none
- MeSH Terms
-
- Animals
- Cells, Cultured
- Dermatitis/drug therapy*
- Guided Tissue Regeneration
- Homeostasis
- Humans
- Keratinocytes/metabolism*
- Lawsonia Plant
- Mice
- Models, Animal
- Naphthoquinones/metabolism*
- Naphthoquinones/therapeutic use
- Receptors, Aryl Hydrocarbon/metabolism*
- Skin/drug effects
- Skin/metabolism*
- Skin/pathology
- Wound Healing
- Zebrafish
- PubMed
- 31350436 Full text @ Sci. Rep.
Citation
Lozza, L., Moura-Alves, P., Domaszewska, T., Lage Crespo, C., Streata, I., Kreuchwig, A., Puyskens, A., Bechtle, M., Klemm, M., Zedler, U., Silviu Ungureanu, B., Guhlich-Bornhof, U., Koehler, A.B., Stäber, M., Mollenkopf, H.J., Hurwitz, R., Furkert, J., Krause, G., Weiner, J., Jacinto, A., Mihai, I., Leite-de-Moraes, M., Siebenhaar, F., Maurer, M., Kaufmann, S.H.E. (2019) The Henna pigment Lawsone activates the Aryl Hydrocarbon Receptor and impacts skin homeostasis. Scientific Reports. 9:10878.
Abstract
As a first host barrier, the skin is constantly exposed to environmental insults that perturb its integrity. Tight regulation of skin homeostasis is largely controlled by the aryl hydrocarbon receptor (AhR). Here, we demonstrate that Henna and its major pigment, the naphthoquinone Lawsone activate AhR, both in vitro and in vivo. In human keratinocytes and epidermis equivalents, Lawsone exposure enhances the production of late epidermal proteins, impacts keratinocyte differentiation and proliferation, and regulates skin inflammation. To determine the potential use of Lawsone for therapeutic application, we harnessed human, murine and zebrafish models. In skin regeneration models, Lawsone interferes with physiological tissue regeneration and inhibits wound healing. Conversely, in a human acute dermatitis model, topical application of a Lawsone-containing cream ameliorates skin irritation. Altogether, our study reveals how a widely used natural plant pigment is sensed by the host receptor AhR, and how the physiopathological context determines beneficial and detrimental outcomes.
Errata / Notes
This article is corrected by ZDB-PUB-220906-205 .
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping