PUBLICATION
A zebrafish tale of parabiosis, podocytes, and proteinuria
- Authors
- Chambers, B.E., Wingert, R.A.
- ID
- ZDB-PUB-190724-32
- Date
- 2019
- Source
- Kidney International 96: 272-275 (Other)
- Registered Authors
- Chambers, Brooke, Wingert, Rebecca
- Keywords
- none
- MeSH Terms
-
- Animals
- Kidney Glomerulus
- Parabiosis
- Podocytes*
- Zebrafish
- Proteinuria
- PubMed
- 31331464 Full text @ Kidney Int.
Citation
Chambers, B.E., Wingert, R.A. (2019) A zebrafish tale of parabiosis, podocytes, and proteinuria. Kidney International. 96:272-275.
Abstract
Glomerular damage is a harbinger of kidney dysfunction. Circulating permeability factors are implicated in causing primary and secondary damage to podocytes, leading to proteinuria and eventual progression to the nephrotic syndrome, but the mechanisms are not well understood. Müller-Deile et al. employed parabiosis with zebrafish embryos and found that a damaged glomerulus can impact a healthy one in a shared circulatory system. This methodology shows promise for elucidating kidney injury pathways in response to systemic disease.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping