PUBLICATION
The Olfactory System of Zebrafish as a Model for the Study of Neurotoxicity and Injury: Implications for Neuroplasticity and Disease
- Authors
- Calvo-Ochoa, E., Byrd-Jacobs, C.A.
- ID
- ZDB-PUB-190418-1
- Date
- 2019
- Source
- International Journal of Molecular Sciences 20(7): (Review)
- Registered Authors
- Byrd-Jacobs, Christine
- Keywords
- injury, neuroplasticity, olfactory bulb, olfactory organ, olfactory system, regeneration, toxicant, zebrafish
- MeSH Terms
-
- Animals
- Disease Models, Animal*
- Neuronal Plasticity*
- Neurotoxicity Syndromes/physiopathology*
- Odorants
- Olfactory Bulb/injuries*
- Olfactory Bulb/pathology
- Zebrafish/physiology*
- PubMed
- 30986990 Full text @ Int. J. Mol. Sci.
Citation
Calvo-Ochoa, E., Byrd-Jacobs, C.A. (2019) The Olfactory System of Zebrafish as a Model for the Study of Neurotoxicity and Injury: Implications for Neuroplasticity and Disease. International Journal of Molecular Sciences. 20(7).
Abstract
The olfactory system, composed of the olfactory organs and the olfactory bulb, allows organisms to interact with their environment and through the detection of odor signals. Olfaction mediates behaviors pivotal for survival, such as feeding, mating, social behavior, and danger assessment. The olfactory organs are directly exposed to the milieu, and thus are particularly vulnerable to damage by environmental pollutants and toxicants, such as heavy metals, pesticides, and surfactants, among others. Given the widespread occurrence of olfactory toxicants, there is a pressing need to understand the effects of these harmful compounds on olfactory function. Zebrafish (Danio rerio) is a valuable model for studying human physiology, disease, and toxicity. Additionally, the anatomical components of the zebrafish olfactory system are similar to those of other vertebrates, and they present a remarkable degree of regeneration and neuroplasticity, making it an ideal model for the study of regeneration, reorganization and repair mechanisms following olfactory toxicant exposure. In this review, we focus on (1) the anatomical, morphological, and functional organization of the olfactory system of zebrafish; (2) the adverse effects of olfactory toxicants and injury to the olfactory organ; and (3) remodeling and repair neuroplasticity mechanisms following injury and degeneration by olfactory toxicant exposure.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping