ZFIN ID: ZDB-PERS-960805-86
Byrd-Jacobs, Christine
Email: christine.byrd@wmich.edu
URL: http://www.wmich.edu/bios/faculty-staff/faculty-profiles/christine.htm
Affiliation: Byrd-Jacobs Lab
Address: Department of Biological Sciences Western Michigan University 1903 W Michigan Ave Kalamazoo, MI 49008-5410 USA
Country: United States
Phone: 269-387-5843
Fax: 269-387-5609

The major focus of my research program is the development and plasticity of the central nervous system. Our model is the olfactory system of zebrafish. The olfactory system is unique in that it is a continually developing sensory system, so we are examining developmental phenomena in an adult animal.

Our work is focused on two areas. The first is an examination of the process of neurogenesis in the adult brain, specifically as it relates to the addition of new cells to the olfactory bulbs. The second area of research is an analysis of how the peripheral olfactory structures affect the maintenance of their central targets. We perform olfactory deafferentations and examine how this manipulation affects the olfactory bulb of adult zebrafish. Both of these topics will lead to a better understanding of the plasticity of the adult brain and the cellular interactions that are important in the maintenance of adult brain structures.

Calvo-Ochoa, E., Byrd-Jacobs, C.A., Fuss, S.H. (2020) Diving into the streams and waves of constitutive and regenerative olfactory neurogenesis: insights from zebrafish. Cell and tissue research. 383(1):227-253
Var, S.R., Byrd-Jacobs, C.A. (2020) Role of Macrophages and Microglia in Zebrafish Regeneration. International Journal of Molecular Sciences. 21(13):
Scheib, J., Byrd-Jacobs, C. (2020) Zebrafish Astroglial Morphology in the Olfactory Bulb Is Altered With Repetitive Peripheral Damage. Frontiers in Neuroanatomy. 14:4
Var, S.R., Byrd-Jacobs, C.A. (2019) Microglial response patterns following damage to the zebrafish olfactory bulb. IBRO reports. 7:70-79
Calvo-Ochoa, E., Byrd-Jacobs, C.A. (2019) The Olfactory System of Zebrafish as a Model for the Study of Neurotoxicity and Injury: Implications for Neuroplasticity and Disease. International Journal of Molecular Sciences. 20(7)
Scheib, J.J., Pozzuto, J.M., Byrd-Jacobs, C.A. (2018) Reversible deafferentation of the zebrafish olfactory bulb with wax pluginsertion. Journal of Neuroscience Methods. 311:47-56
Pozzuto, J.M., Fuller, C.L., Byrd-Jacobs, C.A. (2018) Deafferentation-induced alterations in mitral cell dendritic morphology in the adult zebrafish olfactory bulb. Journal of bioenergetics and biomembranes. 51(1):29-40
Trimpe, D.M., Byrd-Jacobs, C.A. (2016) Patterns of olfactory bulb neurogenesis in the adult zebrafish are altered following reversible deafferentation. Neuroscience. 331:134-47
Hentig, J.T., Byrd-Jacobs, C.A. (2016) Exposure to Zinc Sulfate Results in Differential Effects on Olfactory Sensory Neuron Subtypes in Adult Zebrafish. International Journal of Molecular Sciences. 17(9)
Paskin, T.R., and Byrd-Jacobs, C.A. (2012) Reversible deafferentation of the adult zebrafish olfactory bulb affects glomerular distribution and olfactory-mediated behavior. Behavioural brain research. 235(2):293-301
Paskin, T.R., Iqbal, T.R., and Byrd-Jacobs, C.A. (2011) Olfactory bulb recovery following reversible deafferentation with repeated detergent application in the adult zebrafish. Neuroscience. 196:276-84
Suhr, S.T., Ramachandran, R., Fuller, C.L., Veldman, M.B., Byrd, C.A., and Goldman, D. (2009) Highly-restricted, cell-specific expression of the simian CMV-IE promoter in transgenic zebrafish with age and after heat shock. Gene expression patterns : GEP. 9(1):54-64
Fuller, C.L., Yettaw, H.K., and Byrd, C.A. (2006) Mitral cells in the olfactory bulb of adult zebrafish (Danio rerio): Morphology and distribution. The Journal of comparative neurology. 499(2):218-230
Fuller, C.L., Villanueva, R., and Byrd, C.A. (2005) Changes in glutamate receptor subunit 4 expression in the deafferented olfactory bulb of zebrafish. Brain research. 1044(2):251-261
Fuller, C.L., and Byrd, C.A. (2005) Ruffed cells identified in the adult zebrafish olfactory bulb. Neuroscience letters. 379(3):190-194
Vankirk, A.M. and Byrd, C.A. (2003) Apoptosis following peripheral sensory deafferentation in the olfactory bulb of adult zebrafish. The Journal of comparative neurology. 455(4):488-498
Byrd, C.A. and Brunjes, P.C. (2001) Neurogenesis in the olfactory bulb of adult zebrafish. Neuroscience. 105(4):793-801
Byrd, C.A. (2000) Deafferentation-induced changes in the olfactory bulb of adult zebrafish. Brain research. 866(1-2):92-100
Byrd, C.A. and Brunjes, P.C. (1998) Addition of new cells to the olfactory bulb of adult zebrafish. Annals of the New York Academy of Sciences. 855:274-276
Vogt, R.G., Lindsay, S.M., Byrd, C.A., and Sun, M. (1997) Spatial patterns of olfactory neurons expressing specific odor receptor genes in 48-hour-old embryos of zebrafish, Danio rerio. The Journal of experimental biology. 200:433-443
Byrd, C.A., Jones, J.T., Quattro, J.M., Rogers, M.E., Brunjes, P.C., and Vogt, R.G. (1996) Ontogeny of odorant receptor gene expression in zebrafish, Danio rerio. Journal of neurobiology. 29:445-458
Byrd, C.A. and Brunjes, P.C. (1995) Organization of the olfactory system in the adult zebrafish: histological, immunohistochemical, and quantitative analysis. The Journal of comparative neurology. 358:247-259