PUBLICATION

The mechanobiology of zebrafish cardiac valve leaflet formation

Authors
Paolini, A., Abdelilah-Seyfried, S.
ID
ZDB-PUB-180715-6
Date
2018
Source
Current opinion in cell biology   55: 52-58 (Other)
Registered Authors
Abdelilah-Seyfried, Salim, Paolini, Alessio
Keywords
none
MeSH Terms
  • Animals
  • Biophysical Phenomena*
  • Heart Valves/embryology*
  • Mechanotransduction, Cellular
  • Models, Biological
  • Organogenesis*
  • Zebrafish/embryology*
PubMed
30007126 Full text @ Curr. Opin. Cell Biol.
Abstract
Over a lifetime, rhythmic contractions of the heart provide a continuous flow of blood throughout the body. An essential morphogenetic process during cardiac development which ensures unidirectional blood flow is the formation of cardiac valves. These structures are largely composed of extracellular matrix and of endocardial cells, a specialized population of endothelial cells that line the interior of the heart and that are subjected to changing hemodynamic forces. Recent studies have significantly expanded our understanding of this morphogenetic process. They highlight the importance of the mechanobiology of cardiac valve formation and show how biophysical forces due to blood flow drive biochemical and electrical signaling required for the differentiation of cells to produce cardiac valves.
Genes / Markers
Figures
Expression
Phenotype
Mutation and Transgenics
Human Disease / Model Data
Sequence Targeting Reagents
Fish
Antibodies
Orthology
Engineered Foreign Genes
Mapping
Errata and Notes