PUBLICATION

From fish embryos to human patients: lymphangiogenesis in development and disease

Authors
Mauri, C., Wang, G., Schulte-Merker, S.
ID
ZDB-PUB-180530-12
Date
2018
Source
Current opinion in immunology   53: 167-172 (Other)
Registered Authors
Schulte-Merker, Stefan
Keywords
none
MeSH Terms
  • Animals
  • Embryo, Nonmammalian
  • Fishes
  • Genome-Wide Association Study
  • Homeostasis
  • Humans
  • Immunologic Surveillance
  • Lipid Metabolism
  • Lymphangiogenesis*
  • Lymphatic Vessels/physiology*
  • Lymphedema/genetics*
  • Lymphedema/immunology
  • Mice
  • Signal Transduction
  • Vascular Endothelial Growth Factor Receptor-3/metabolism
PubMed
29800868 Full text @ Curr. Opin. Immunol.
Abstract
The lymphatic vasculature plays vital roles in immune surveillance, fluid homeostasis and fat absorption in the body. Lined by endothelial cells, the lymphatic system is functionally distinct from the blood vasculature, and fulfills different physiological functions. In recent years, insight from zebrafish, mice and human patients have improved our understanding of lymphatics, and the interplay between zebrafish genetics, studies in mice and GWAS analysis in human patients have identified genes that, when mutated, will lead to lymphedema formation. Here, we focus on components of the Vegfr3 pathway, and how they are connected to Milroy disease and Hennekam syndrome.
Genes / Markers
Figures
Expression
Phenotype
Mutation and Transgenics
Human Disease / Model Data
Sequence Targeting Reagents
Fish
Antibodies
Orthology
Engineered Foreign Genes
Mapping
Errata and Notes