PUBLICATION

Characterization of the caspase family in zebrafish

Authors
Spead, O., Verreet, T., Donelson, C.J., Poulain, F.E.
ID
ZDB-PUB-180526-5
Date
2018
Source
PLoS One   13: e0197966 (Journal)
Registered Authors
Poulain, Fabienne
Keywords
none
MeSH Terms
  • Amino Acid Sequence
  • Animals
  • Caspases/chemistry
  • Caspases/genetics
  • Caspases/metabolism*
  • Cloning, Molecular
  • Gene Expression Regulation, Developmental
  • Humans
  • Phylogeny
  • Zebrafish*/genetics
  • Zebrafish*/growth & development
PubMed
29791492 Full text @ PLoS One
Abstract
First discovered for their role in mediating programmed cell death and inflammatory responses, caspases have now emerged as crucial regulators of other cellular and physiological processes including cell proliferation, differentiation, migration, and survival. In the developing nervous system, for instance, the non-apoptotic functions of caspases have been shown to play critical roles in the formation of neuronal circuits by regulating axon outgrowth, guidance and pruning. How caspase activity is spatially and temporally maintained at sub-lethal levels within cells remains however poorly understood, especially in vivo. Thanks to its transparency and accessibility, the zebrafish offers the unique ability to directly visualize caspase activation in vivo. Yet, detailed information about the caspase family in zebrafish is lacking. Here, we report the identification and characterization of 19 different caspase genes in zebrafish, and show that caspases have diverse expression profiles from cleavage to larval stages, suggesting highly specialized and/or redundant functions during embryonic development.
Genes / Markers
Figures
Expression
Phenotype
Mutation and Transgenics
Human Disease / Model Data
Sequence Targeting Reagents
Fish
Antibodies
Orthology
Engineered Foreign Genes
Mapping
Errata and Notes