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ZFIN ID: ZDB-PUB-180201-8
New models to study vascular mural cell embryonic origin: implications in vascular diseases
Sinha, S., Santoro, M.M.
Date: 2018
Source: Cardiovascular research   114(4): 481-491 (Review)
Registered Authors: Santoro, Massimo
Keywords: none
MeSH Terms:
  • Animals
  • Cell Communication
  • Cell Lineage*
  • Embryonic Stem Cells/metabolism
  • Embryonic Stem Cells/pathology*
  • Gene Expression Regulation, Developmental
  • Humans
  • Induced Pluripotent Stem Cells/metabolism
  • Induced Pluripotent Stem Cells/pathology*
  • Myocytes, Smooth Muscle/metabolism
  • Myocytes, Smooth Muscle/pathology*
  • Neovascularization, Physiologic
  • Phenotype
  • Signal Transduction
  • Vascular Diseases/genetics
  • Vascular Diseases/metabolism
  • Vascular Diseases/pathology*
  • Vascular Diseases/physiopathology
  • Zebrafish/genetics
  • Zebrafish/metabolism
PubMed: 29385541 Full text @ Cardiovasc. Res.
A key question in vascular biology is how the diversity of origin of vascular mural cells, namely smooth muscle cells and pericytes influences vessel properties, in particular the regional propensity to vascular diseases. This review therefore first describes the role and regulation of mural cells during vascular formation, with a focus on embryonic origin. We then consider the evidence that connects heterogeneities in smooth muscle cell and pericyte origins with disease. Since this idea has major implications for understanding and modelling human disease, then there is a pressing need for new model systems to investigate mural cell development and the consequences of heterogeneity. Recent advances arising from in vitro strategies for deriving mural cells from human pluripotent stem cells as well as from the zebrafish model will be discussed and the medical relevance of these discoveries will be highlighted.