ZFIN Person: Santoro, Massimo

ZFIN ID: ZDB-PERS-080228-1

ZFIN ID: ZDB-PERS-080228-1

Santoro, Massimo

Email:	massimo.santoro@unipd.it
URL:	http://massimomsantoro.wixsite.com/santorolab
Affiliation:	Santoro Lab
Address:	Massimo M. Santoro, PhD Full Professor and Chair Cellular and Molecular Biology Dept. of Biology Viale G. Colombo 3, University of Padua 35131 Padova
Country:	Italy
Phone:	+39 049 827 6270
Fax:
ORCID ID:

BIOGRAPHY AND RESEARCH INTERESTS

PUBLICATIONS

Facchinello, N., Astone, M., Audano, M., Oberkersch, R.E., Spizzotin, M., Calura, E., Marques, M., Crisan, M., Mitro, N., Santoro, M.M. (2022) Oxidative pentose phosphate pathway controls vascular mural cell coverage by regulating extracellular matrix composition. Nature metabolism. 4:123-140

Camillo, C., Facchinello, N., Villari, G., Mana, G., Gioelli, N., Sandri, C., Astone, M., Tortarolo, D., Clapero, F., Gays, D., Oberkersch, R.E., Arese, M., Tamagnone, L., Valdembri, D., Santoro, M.M., Serini, G. (2021) LPHN2 inhibits vascular permeability by differential control of endothelial cell adhesion. The Journal of cell biology. 220(11):

Facchinello, N., Laquatra, C., Locatello, L., Beffagna, G., Brañas Casas, R., Fornetto, C., Dinarello, A., Martorano, L., Vettori, A., Risato, G., Celeghin, R., Meneghetti, G., Santoro, M.M., Delahodde, A., Vanzi, F., Rasola, A., Dalla Valle, L., Rasotto, M.B., Lodi, T., Baruffini, E., Argenton, F., Tiso, N. (2021) Efficient clofilium tosylate-mediated rescue of POLG-related disease phenotypes in zebrafish. Cell Death & Disease. 12:100

Santoro, M.M., Beltrame, M., Panáková, D., Siekmann, A.F., Tiso, N., Venero Galanternik, M., Jung, H.M., Weinstein, B.M. (2019) Advantages and Challenges of Cardiovascular and Lymphatic Studies in Zebrafish Research. Frontiers in cell and developmental biology. 7:89

Dickmeis, T., Feng, Y., Mione, M.C., Ninov, N., Santoro, M., Spaink, H.P., Gut, P. (2019) Nano-Sampling and Reporter Tools to Study Metabolic Regulation in Zebrafish. Frontiers in cell and developmental biology. 7:15

Norris, D.M., Santoro, M.M. (2018) Before the Pump. Arteriosclerosis, Thrombosis, and Vascular Biology. 38:2763-2764

Stone, O.A., El-Brolosy, M., Wilhelm, K., Liu, X., Romão, A.M., Grillo, E., Lai, J.K.H., Günther, S., Jeratsch, S., Kuenne, C., Lee, I.C., Braun, T., Santoro, M.M., Locasale, J.W., Potente, M., Stainier, D.Y.R. (2018) Loss of pyruvate kinase M2 limits growth and triggers innate immune signaling in endothelial cells. Nature communications. 9:4077

Sinha, S., Santoro, M.M. (2018) New models to study vascular mural cell embryonic origin: implications in vascular diseases. Cardiovascular research. 114(4):481-491

Louw, J.J., Nunes Bastos, R., Chen, X., Verdood, C., Corveleyn, A., Jia, Y., Breckpot, J., Gewillig, M., Peeters, H., Santoro, M.M., Barr, F., Devriendt, K. (2018) Compound heterozygous loss-of-function mutations in KIF20A are associated with a novel lethal congenital cardiomyopathy in two siblings. PLoS Genetics. 14:e1007138

Panieri, E., Millia, C., Santoro, M.M. (2017) Real-time quantification of subcellular H2O2 and glutathione redox potential in living cardiovascular tissues.. Free radical biology & medicine. 109:189-200

Panieri, E., Santoro, M.M. (2017) Data on metabolic-dependent antioxidant response in the cardiovascular tissues of living zebrafish under stress conditions. Data in brief. 12:427-432

Gays, D., Hess, C., Camporeale, A., Ala, U., Provero, P., Mosimann, C., Santoro, M.M. (2017) An exclusive cellular and molecular network governs intestinal smooth muscle cell differentiation in vertebrates. Development (Cambridge, England). 144(3):464-478

Chen, X., Gays, D., Milia, C., Santoro, M.M. (2017) Cilia Control Vascular Mural Cell Recruitment in Vertebrates. Cell Reports. 18:1033-1047

Mana, G., Clapero, F., Panieri, E., Panero, V., Böttcher, R.T., Tseng, H.Y., Saltarin, F., Astanina, E., Wolanska, K.I., Morgan, M.R., Humphries, M.J., Santoro, M.M., Serini, G., Valdembri, D. (2016) PPFIA1 drives active α5β1 integrin recycling and controls fibronectin fibrillogenesis and vascular morphogenesis. Nature communications. 7:13546

Chen, X., Gays, D., Santoro, M.M. (2016) Transgenic Zebrafish. Methods in molecular biology (Clifton, N.J.). 1464:107-114

Martano, C., Mugoni, V., Dal Bello, F., Santoro, M.M., Medana, C. (2015) Rapid high performance liquid chromatography-high resolution mass spectrometry methodology for multiple prenol lipids analysis in zebrafish embryos. Journal of chromatography. A. 1412:59-66

Garaffo, G., Conte, D., Provero, P., Tomaiuolo, D., Luo, Z., Pinciroli, P., Peano, C., D'Atri, I., Gitton, Y., Etzion, T., Gothilf, Y., Gays, D., Santoro, M.M., Merlo, G.R. (2015) The Dlx5 and Foxg1 transcription factors, linked via miRNA-9 and -200, are required for the development of the olfactory and GnRH system. Molecular and cellular neurosciences. 68:103-19

Fortuna, V., Pardanaud, L., Brunet, I., Ola, R., Ristori, E., Santoro, M.M., Nicoli, S., Eichmann, A. (2015) Vascular Mural Cells Promote Noradrenergic Differentiation of Embryonic Sympathetic Neurons. Cell Reports. 11(11):1786-96

Mercurio, S., Petrillo, S., Chiabrando, D., Bassi, Z.I., Gays, D., Camporeale, A., Vacaru, A., Miniscalco, B., Valperga, G., Silengo, L., Altruda, F., Baron, M.H., Santoro, M.M., Tolosano, E. (2015) The Heme Exporter Flvcr1 Regulates Expansion And Differentiation Of Committed Erythroid Progenitors By Controlling Intracellular Heme Accumulation. Haematologica. 100(6):720-9

Santoro, M.M. (2014) Zebrafish as a model to explore cell metabolism. Trends in endocrinology and metabolism: TEM. 25(10):546-554

Goodman, K.M., Kjær, S., Beuron, F., Knowles, P.P., Nawrotek, A., Burns, E.M., Purkiss, A.G., George, R., Santoro, M., Morris, E.P., McDonald, N.Q. (2014) RET recognition of GDNF-GFRα1 ligand by a composite binding site promotes membrane-proximal self-association. Cell Reports. 8:1894-904

Santoro, M.M. (2014) Antiangiogenic Cancer Drug Using the Zebrafish Model. Arterioscler. Thromb. Vasc. Biol.. 34(9):1846-53

Mugoni, V., Camporeale, A., Santoro, M.M. (2014) Analysis of Oxidative Stress in Zebrafish Embryos. Journal of visualized experiments : JoVE. (89)

Whitesell, T.R., Kennedy, R.M., Carter, A.D., Rollins, E.L., Georgijevic, S., Santoro, M.M., Childs, S.J. (2014) An alpha-smooth muscle actin (acta2/alphasma) zebrafish transgenic line marking vascular mural cells and visceral smooth muscle cells. PLoS One. 9:e90590

Garaffo, G., Provero, P., Molineris, I., Pinciroli, P., Peano, C., Battaglia, C., Tomaiuolo, D., Etzion, T., Gothilf, Y., Santoro, M., and Merlo, G.R. (2013) Profiling, Bioinformatic, and Functional Data on the Developing Olfactory/GnRH System Reveal Cellular and Molecular Pathways Essential for This Process and Potentially Relevant for the Kallmann Syndrome. Frontiers in Experimental Endocrinology. 4:203

Mugoni, V., Medana, C., and Santoro, M.M. (2013) (13)C-isotope-based protocol for prenyl lipid metabolic analysis in zebrafish embryos. Nature Protocols. 8(12):2337-2347

Gays, D., and Santoro, M.M. (2013) The admiR-able advances in cardiovascular biology through the zebrafish model system. Cellular and molecular life sciences : CMLS. 70(14):2489-503

Follo, C., Ozzano, M., Montalenti, C., Santoro, M.M., and Isidoro, C. (2013) Knock-down of Cathepsin D in zebrafish fertilized eggs determines congenital myopathy. Bioscience Reports. 33(2):e00034

Mugoni, V., Postel, R., Catanzaro, V., De Luca, E., Turco, E., Digilio, G., Silengo, L., Murphy, M.P., Medana, C., Stainier, D.Y., Bakkers, J., and Santoro, M.M. (2013) Ubiad1 Is an Antioxidant Enzyme that Regulates eNOS Activity by CoQ10 Synthesis. Cell. 152(3):504-518

Santoro, M.M. (2011) "Fishing" for endothelial microRNA functions and dysfunction. Vascular Pharmacology. 55(4):60-8

Follo, C., Ozzano, M., Mugoni, V., Castino, R., Santoro, M., and Isidoro, C. (2011) Knock-down of cathepsin D affects the retinal pigment epithelium, impairs swim-bladder ontogenesis and causes premature death in zebrafish. PLoS One. 6(7):e21908

Grimes, A.C., Durán, A.C., Sans-Coma, V., Hami, D., Santoro, M.M., and Torres, M. (2010) Phylogeny informs ontogeny: a proposed common theme in the arterial pole of the vertebrate heart. Evolution & development. 12(6):552-567

Santoro, M.M., Pesce, G., and Stainier, D.Y. (2009) Characterization of vascular mural cells during zebrafish development. Mechanisms of Development. 126(8-9):638-649

Gyrd-Hansen, M., Darding, M., Miasari, M., Santoro, M.M., Zender, L., Xue, W., Tenev, T., da Fonseca, P.C., Zvelebil, M., Bujnicki, J.M., Lowe, S., Silke, J., and Meier, P. (2008) IAPs contain an evolutionarily conserved ubiquitin-binding domain that regulates NF-kappaB as well as cell survival and oncogenesis. Nature cell biology. 10(11):1309-1317

Fish, J.E., Santoro, M.M., Morton, S.U., Yu, S., Yeh, R.F., Wythe, J.D., Ivey, K.N., Bruneau, B.G., Stainier, D.Y., and Srivastava, D. (2008) miR-126 regulates angiogenic signaling and vascular integrity. Developmental Cell. 15(2):272-284

Santoro, M.M., Samuel, T., Mitchell, T., Reed, J.C., and Stainier, D.Y. (2007) Birc2 (cIap1) regulates endothelial cell integrity and blood vessel homeostasis. Nature Genetics. 39(11):1397-1402

Jin, S.W., Herzog, W., Santoro, M.M., Mitchell, T.S., Frantsve, J., Jungblut, B., Beis, D., Scott, I.C., D'Amico, L.A., Ober, E.A., Verkade, H., Field, H.A., Chi, N.C., Wehman, A.M., Baier, H., and Stainier, D.Y. (2007) A transgene-assisted genetic screen identifies essential regulators of vascular development in vertebrate embryos. Developmental Biology. 307(1):29-42

NON-ZEBRAFISH PUBLICATIONS
Chianale F, Cutrupi S, Rainero E, Baldanzi G, Porporato PE, Traini S, Filigheddu N, Gnocchi VF, Santoro MM, Parolini O, van Blitterswijk WJ, Sinigaglia F, Graziani A. Diacylglycerol Kinase-{alpha} Mediates HGF-induced Epithelial Cell Scatter by Regulating Rac Activation and Membrane Ruffling. Mol Biol Cell. 18, 4859 – 4871, 2007.

S. Germano, D. Barberis, M. M. Santoro, L. Penengo, Ami Citri, Y. Yarden and G. Gaudino.
Geldanamycin triggers a novel Ron degradative pathway hampering oncogenic signalling.
Journal of Biological Chemistry, 281 (31) 21710-9, 2006.

M.M. Santoro and G. Gaudino. Cellular and molecular facets of keratinocyte reepithelization during wound healing. Exp Cell Res. 304: 274-86, 2005.

M.M. Santoro, G. Gaudino and E. Villa. Protein phosphatase-1 binds to phosphoserine 1394 of the MSP receptor. Biochemical Journal, 376: 587-94, 2003

M.M. Santoro, G. Gaudino and P.C. Marchisio. The MSP receptor regulates ±6²4 and ±3²1 integrins via 14-3-3 proteins in keratinocyte re-epithelization. Developmental Cell, 5: 257-271, 2003.