PUBLICATION

How to Plumb a Pisces: Understanding Vascular Development and Disease Using Zebrafish Embryos

Authors
Hogan, B.M., Schulte-Merker, S.
ID
ZDB-PUB-170928-8
Date
2017
Source
Developmental Cell   42: 567-583 (Review)
Registered Authors
Hogan, Ben M., Schulte-Merker, Stefan
Keywords
angiogenesis, blood vessel, lymphangiogenesis, lymphatic, vascular, vascular disease, vasculogenesis, zebrafish
MeSH Terms
  • Animals
  • Blood Vessels/embryology*
  • Blood Vessels/pathology*
  • Body Patterning
  • Disease Models, Animal
  • Embryo, Nonmammalian/metabolism*
  • Neovascularization, Physiologic
  • Zebrafish/embryology*
PubMed
28950100 Full text @ Dev. Cell
Abstract
Our vasculature plays diverse and critical roles in homeostasis and disease. In recent decades, the use of zebrafish has driven our understanding of vascular development into new areas, identifying new genes and mechanisms controlling vessel formation and allowing unprecedented observation of the cellular and molecular events that shape the developing vasculature. Here, we highlight key mechanisms controlling formation of the zebrafish vasculature and investigate how knowledge from this highly tractable model system has informed our understanding of vascular disease in humans.
Genes / Markers
Figures
Expression
Phenotype
Mutation and Transgenics
Human Disease / Model Data
Sequence Targeting Reagents
Fish
Antibodies
Orthology
Engineered Foreign Genes
Mapping
Errata and Notes