PUBLICATION
Pushing Yap into the Nucleus with Shear Force
- Authors
- Lai, J.K., Stainier, D.Y.
- ID
- ZDB-PUB-170330-9
- Date
- 2017
- Source
- Developmental Cell 40: 517-518 (Review)
- Registered Authors
- Stainier, Didier
- Keywords
- none
- MeSH Terms
-
- Animals
- Cell Nucleus
- Endothelial Cells*
- Endothelium
- Stress, Mechanical*
- Zebrafish
- PubMed
- 28350983 Full text @ Dev. Cell
Citation
Lai, J.K., Stainier, D.Y. (2017) Pushing Yap into the Nucleus with Shear Force. Developmental Cell. 40:517-518.
Abstract
Endothelial cells line blood vessels and experience shear stress from blood flow. In this issue of Developmental Cell, Nakajima and colleagues (2017) show that in zebrafish Yap responds to blood flow by translocating into the nucleus, where it drives a genetic program to maintain vascular stability.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping