ZFIN ID: ZDB-PUB-170330-9
Pushing Yap into the Nucleus with Shear Force
Lai, J.K., Stainier, D.Y.
Date: 2017
Source: Developmental Cell 40: 517-518 (Review)
Registered Authors: Stainier, Didier
Keywords: none
MeSH Terms: Animals; Cell Nucleus; Endothelial Cells*; Endothelium; Stress, Mechanical* (all 6) expand
PubMed: 28350983 Full text @ Dev. Cell
ABSTRACT
Endothelial cells line blood vessels and experience shear stress from blood flow. In this issue of Developmental Cell, Nakajima and colleagues (2017) show that in zebrafish Yap responds to blood flow by translocating into the nucleus, where it drives a genetic program to maintain vascular stability.
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