PUBLICATION

Left Habenula Mediates Light-Preference Behavior in Zebrafish via an Asymmetrical Visual Pathway

Authors
Zhang, B.B., Yao, Y.Y., Zhang, H.F., Kawakami, K., Du, J.L.
ID
ZDB-PUB-170214-12
Date
2017
Source
Neuron   93(4): 914-928.e4 (Journal)
Registered Authors
Du, Jiu Lin, Kawakami, Koichi, Zhang, Hefei
Keywords
asymmetry, eminentia thalami, habenula, in vivo electrophysiological recording, in vivo imaging, light-preference behavior, retinal ganglion cell, thigmotaxis, zebrafish
MeSH Terms
  • Animals
  • Behavior, Animal
  • Body Patterning/physiology*
  • Larva/metabolism
  • Visual Pathways/metabolism*
  • Thalamus/metabolism
  • Central Nervous System/metabolism
  • Neurons/metabolism*
  • Zebrafish Proteins/metabolism
  • Animals, Genetically Modified
  • Zebrafish
  • Light*
(all 12)
PubMed
28190643 Full text @ Neuron
Abstract
Habenula (Hb) plays critical roles in emotion-related behaviors through integrating inputs mainly from the limbic system and basal ganglia. However, Hb also receives inputs from multiple sensory modalities. The function and underlying neural circuit of Hb sensory inputs remain unknown. Using larval zebrafish, we found that left dorsal Hb (dHb, a homolog of mammalian medial Hb) mediates light-preference behavior by receiving visual inputs from a specific subset of retinal ganglion cells (RGCs) through eminentia thalami (EmT). Loss- and gain-of-function manipulations showed that left, but not right, dHb activities, which encode environmental illuminance, are necessary and sufficient for light-preference behavior. At circuit level, left dHb neurons receive excitatory monosynaptic inputs from bilateral EmT, and EmT neurons are contacted mainly by sustained ON-type RGCs at the arborization field 4 of retinorecipient brain areas. Our findings discover a previously unidentified asymmetrical visual pathway to left Hb and its function in mediating light-preference behavior.
Genes / Markers
Figures
Figure Gallery (8 images)
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Expression
No data available
Phenotype
No data available
Mutations / Transgenics
Allele Construct Type Affected Genomic Region
c375TgTransgenic Insertion
    c426TgTransgenic Insertion
      icm21TgTransgenic Insertion
        ion13dTgTransgenic Insertion
          ion14dTgTransgenic Insertion
            ion27dTgTransgenic Insertion
            s1020tEtTransgenic Insertion
              s1984tTgTransgenic Insertion
                s1985tTgTransgenic Insertion
                  s1992tTgTransgenic Insertion
                    1 - 10 of 10
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                    Human Disease / Model
                    No data available
                    Sequence Targeting Reagents
                    No data available
                    Fish
                    No data available
                    Antibodies
                    Name Type Antigen Genes Isotypes Host Organism
                    Ab1-calb2polyclonalRabbit
                    1 - 1 of 1
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                    Orthology
                    No data available
                    Engineered Foreign Genes
                    Marker Marker Type Name
                    BoTxBLCEFGBoTxBLC
                    EGFPEFGEGFP
                    GAL4EFGGAL4
                    GAL4FFEFGGAL4FF
                    GCaMPEFGGCaMP
                    GFPEFGGFP
                    mCherryEFGmCherry
                    1 - 7 of 7
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                    Mapping
                    No data available
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                    Citation
                    Zhang, B.B., Yao, Y.Y., Zhang, H.F., Kawakami, K., Du, J.L. (2017) Left Habenula Mediates Light-Preference Behavior in Zebrafish via an Asymmetrical Visual Pathway. Neuron. 93(4):914-928.e4.