PUBLICATION
Establishment of a drug evaluation model against light-induced retinal degeneration using adult pigmented zebrafish
- Authors
- Saito, Y., Tsuruma, K., Shimazawa, M., Nishimura, Y., Tanaka, T., Hara, H.
- ID
- ZDB-PUB-160721-6
- Date
- 2016
- Source
- Journal of Pharmacological Sciences 131(3): 215-8 (Journal)
- Registered Authors
- Tanaka, Toshio
- Keywords
- Dry age-related macular degeneration, Pigmented retina, Zebrafish
- MeSH Terms
-
- Acetylcysteine/administration & dosage
- Acetylcysteine/therapeutic use*
- Administration, Ophthalmic
- Animals
- Disease Models, Animal*
- Light*
- Macular Degeneration/drug therapy*
- Macular Degeneration/etiology
- Vitreous Body
- Zebrafish
- PubMed
- 27430989 Full text @ J. Pharmacol. Sci.
Citation
Saito, Y., Tsuruma, K., Shimazawa, M., Nishimura, Y., Tanaka, T., Hara, H. (2016) Establishment of a drug evaluation model against light-induced retinal degeneration using adult pigmented zebrafish. Journal of Pharmacological Sciences. 131(3):215-8.
Abstract
Age-related macular degeneration (AMD) is a major cause of irreversible loss of central vision in the elderly. Zebrafish is an attractive animal model in some respects, lower cost, smaller housing facilities and easier genetic manipulation compared to rodents. The present study aimed to establish a drug evaluation method against light irradiation, as a dry AMD disease model, using adult pigmented zebrafish. Intravitreal administration of an antioxidant, N-acetylcysteine, protected against light-induced retinal degeneration in a concentration-dependent manner. We established a new drug evaluation model against light-induced retinal degeneration that can provide new knowledge about dry AMD pathology and therapy.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping