PUBLICATION
Endoderm specification and liver development
- Authors
- Goessling, W., Stainier, D.Y.
- ID
- ZDB-PUB-160618-9
- Date
- 2016
- Source
- Methods in cell biology 134: 463-83 (Chapter)
- Registered Authors
- Goessling, Wolfram, Stainier, Didier
- Keywords
- Biliary tract, Endoderm, Liver, Liver regeneration, Zebrafish
- MeSH Terms
-
- Animals
- Body Patterning/genetics*
- Digestive System/growth & development
- Endoderm/growth & development*
- Liver/growth & development*
- Morphogenesis/genetics
- Pancreas/growth & development
- Zebrafish/genetics
- Zebrafish/growth & development*
- PubMed
- 27312502 Full text @ Meth. Cell. Biol.
Citation
Goessling, W., Stainier, D.Y. (2016) Endoderm specification and liver development. Methods in cell biology. 134:463-83.
Abstract
The endoderm is the innermost embryonic germ layer, and in zebrafish, it gives rise to the lining of the gut, the gills, liver, pancreas, gallbladder, and derivatives of the pharyngeal pouch. These organs form the gastrointestinal tract and are involved with the absorption, delivery, and metabolism of nutrients. The liver has a central role in regulating these processes because it controls carbohydrate and lipid metabolism, protein synthesis, and breakdown of endogenous and xenobiotic products. Liver dysfunction frequently leads to significant morbidity and mortality; however, in most settings of organ injury, the liver exhibits remarkable regenerative capacity. In this chapter, we review the principal mechanisms of endoderm and liver formation and provide protocols to assess liver formation and liver regeneration.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping