PUBLICATION

Yap/Taz transcriptional activity in endothelial cells promotes intramembranous ossification via the BMP pathway

Authors
Uemura, M., Nagasawa, A., Terai, K.
ID
ZDB-PUB-160610-11
Date
2016
Source
Scientific Reports   6: 27473 (Journal)
Registered Authors
Keywords
Bone development, Differentiation, Reporter genes
MeSH Terms
  • Animals
  • Bone Morphogenetic Proteins/metabolism*
  • Core Binding Factor Alpha 1 Subunit/genetics
  • Osteogenesis*
  • Transcription Factors/metabolism*
  • Transcription, Genetic
  • Transcriptional Activation
  • Zebrafish
PubMed
27273480 Full text @ Sci. Rep.
Citation
Uemura, M., Nagasawa, A., Terai, K. (2016) Yap/Taz transcriptional activity in endothelial cells promotes intramembranous ossification via the BMP pathway. Scientific Reports. 6:27473.
Abstract
Osteogenesis is categorized into two groups based on developmental histology, intramembranous and endochondral ossification. The role of blood vessels during endochondral ossification is well known, while their role in intramembranous ossification, especially the intertissue pathway, is poorly understood. Here, we demonstrate endothelial Yap/Taz is a novel regulator of intramembranous ossification in zebrafish. Appropriate blood flow is required for Yap/Taz transcriptional activation in endothelial cells and intramembranous ossification. Additionally, Yap/Taz transcriptional activity in endothelial cells specifically promotes intramembranous ossification. BMP expression by Yap/Taz transactivation in endothelial cells is also identified as a bridging factor between blood vessels and intramembranous ossification. Furthermore, the expression of Runx2 in pre-osteoblast cells is a downstream target of Yap/Taz transcriptional activity in endothelial cells. Our results provide novel insight into the relationship between blood flow and ossification by demonstrating intertissue regulation.
Genes / Markers
Figures
Show all Figures
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Antibodies
Orthology
Engineered Foreign Genes
Mapping
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