PUBLICATION
Progress into the etiology of intracerebral hemorrhage (ICH): Insights from Zebrafish embryos
- Authors
- Eisa-Beygi, S., Rezaei, M.
- ID
- ZDB-PUB-160603-6
- Date
- 2016
- Source
- The International journal of developmental biology 60(4-5-6): 119-126 (Review)
- Registered Authors
- Eisa-Beygi, Shahram
- Keywords
- intracerebral hemorrhage, neurovascular development, stroke etiology, zebrafish
- MeSH Terms
-
- Animals
- Animals, Genetically Modified
- Cerebral Hemorrhage/genetics*
- Disease Models, Animal
- Signal Transduction/genetics
- Stroke/genetics*
- Zebrafish/genetics
- PubMed
- 27251071 Full text @ Int. J. Dev. Biol.
Citation
Eisa-Beygi, S., Rezaei, M. (2016) Progress into the etiology of intracerebral hemorrhage (ICH): Insights from Zebrafish embryos. The International journal of developmental biology. 60(4-5-6):119-126.
Abstract
Intracerebral hemorrhage (ICH) is the most severe subtype of stroke. Treatment options are scarce and given the high morbidity and mortality, relatively ineffective. Since patients with ICH may have an unknown heritable component, the need to identify potential risk factors necessitates the use of animal models to elucidate the genetic underpinnings of neurovascular development and, thereby, identify candidate regulatory pathways that are likely to be disrupted in patients with ICH. Zebrafish (Danio rerio) exhibits the anatomical and physiological complexity of a closed circulatory system observed in all vertebrates (with arteries, veins and capillaries). Moreover, studies over the last decade, aided by the application of chemical mutagenesis screens, morpholino mediated knockdown approaches and tissue-specific transgenic markers, have paved the way for the identification of several genes and signaling pathways that regulate developmental neurovascular stabilization. We hypothesize that mutations in these genes or pharmacological perturbations of these gene-products may account, at least in part, for the etiology of some forms of spontaneous ICH in humans.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping