ZFIN ID: ZDB-PERS-150811-1
Eisa-Beygi, Shahram
Email: seisabeygi@mcw.edu
Affiliation: MCW Radiology - Zebrafish
Address: Shahram Eisa-Beygi (PhD) Radiology Medical College of Wisconsin & Children's Hospital of Wisconsin 8701 Watertown Plank Road Milwaukee, Wisconsin, USA 53226 Tel: 1-414-551-4536
Country: United States

The goal of my research is to understand how blood vessels in the brain develop to form an inter-connected, stable and perfused network that continuously supply oxygen, nutrients and cellular factors to the developing brain. I use zebrafish (Danio rerio), a genetically tractable vertebrate model, to understand the mechanisms of neuro-vascular development, with a focus on the etiology of paediatric cerebral-vascular malformations, including cerebral aneurysms, arteriovenous malformations (AVMs) and cerebral cavernous malformations (CCMs).

Pourghadamyari, H., Rezaei, M., Ipakchi-Azimi, A., Eisa-Beygi, S., Basiri, M., Tahamtani, Y., Baharvand, H. (2019) Establishing a new animal model for muscle regeneration studies. Molecular biology research communications. 8:171-179
Eisa-Beygi, S., Benslimane, F.M., El-Rass, S., Prabhudesai, S., Abdelrasoul, M.K.A., Simpson, P.M., Yalcin, H.C., Burrows, P.E., Ramchandran, R. (2018) Characterization of Endothelial Cilia Distribution During Cerebral-Vascular Development in Zebrafish ( Danio rerio). Arteriosclerosis, Thrombosis, and Vascular Biology. 38:2806-2818
Prabhudesai, S., Koceja, C., Dey, A., Eisa-Beygi, S., Leigh, N.R., Bhattacharya, R., Mukherjee, P., Ramchandran, R. (2018) Corrigendum: Cystathionine β-Synthase Is Necessary for Axis Development in vivo.. Frontiers in cell and developmental biology. 6:121
Chowdhury, T.A., Koceja, C., Eisa-Beygi, S., Kleinstiver, B.P., Kumar, S.N., Lin, C.W., Li, K., Prabhudesai, S., Joung, J.K., Ramchandran, R. (2018) Temporal and Spatial Post-Transcriptional Regulation of Zebrafish tie1 mRNA by Long Noncoding RNA During Brain Vascular Assembly.. Arteriosclerosis, Thrombosis, and Vascular Biology. 38(7):1562-1575
Prabhudesai, S., Koceja, C., Dey, A., Eisa-Beygi, S., Leigh, N.R., Bhattacharya, R., Mukherjee, P., Ramchandran, R. (2018) Cystathionine β-Synthase Is Necessary for Axis Development in Vivo.. Frontiers in cell and developmental biology. 6:14
El-Rass, S., Eisa-Beygi, S., Khong, E., Brand-Arzamendi, K., Mauro, A., Zhang, H., Clark, K.J., Ekker, S.C., Wen, X.Y. (2017) Disruption of pdgfra alters endocardial and myocardial fusion during zebrafish cardiac assembly.. Biology Open. 6(3):348-357
Eisa-Beygi, S., Rezaei, M. (2016) Progress into the etiology of intracerebral hemorrhage (ICH): Insights from Zebrafish embryos. The International journal of developmental biology. 60(4-5-6):119-126
Eisa-Beygi, S., Macdonald, R.L., Wen, X.Y. (2014) Regulatory pathways affecting vascular stabilization via VE-cadherin dynamics: insights from zebrafish (Danio rerio). Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 34(9):1430-3
Eisa-Beygi, S., Ekker, M., Moon, T.W., Macdonald, R.L., Wen, X.Y. (2014) Developmental processes regulated by the 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR) pathway: Highlights from animal studies. Reproductive toxicology (Elmsford, N.Y.). 46C:115-120
Eisa-Beygi, S., Wen, X.Y., Macdonald, R.L. (2014) A Call for Rigorous Study of Statins in Resolution of Cerebral Cavernous Malformation Pathology. Stroke. 45(6):1859-61
Massarsky, A., Strek, L., Craig, P.M., Eisa-Beygi, S., Trudeau, V.L., and Moon, T.W. (2014) Acute embryonic exposure to nanosilver or silver ion does not disrupt the stress response in zebrafish (Danio rerio) larvae and adults. The Science of the total environment. 478:133-140
Massarsky, A., Dupuis, L., Taylor, J., Eisa-Beygi, S., Strek, L., Trudeau, V.L., and Moon, T.W. (2013) Assessment of nanosilver toxicity during zebrafish (Danio rerio) development. Chemosphere. 92(1):59-66
Eisa-Beygi, S., Hatch, G., Noble, S., Ekker, M., and Moon, T.W. (2013) The 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR) pathway regulates developmental cerebral-vascular stability via prenylation-dependent signalling pathway. Developmental Biology. 373(2):258-266
Eisa-Beygi, S. (2013) HMGCR Pathway Mediates Cerebral-Vascular Stability and Angiogenesis in Developing Zebrafish.. Ph.D. Thesis.

Eisa-Beygi S, Wen XY. (2015). “Could pharmacological curtailment of RhoA/Rho-kinase (ROCK) pathway attenuate the endothelial barrier dysfunction associated with Ebola virus (EBOV) infection?” Antiviral Research. 114:53-56.