PUBLICATION
Little fish, big catch: zebrafish as a model for kidney disease
- Authors
- Poureetezadi, S.J., Wingert, R.A.
- ID
- ZDB-PUB-160512-7
- Date
- 2016
- Source
- Kidney International 89(6): 1204-10 (Review)
- Registered Authors
- Poureetezadi, Shahram, Wingert, Rebecca
- Keywords
- acute kidney injury, glomerulus, nephrotoxity, renal pathology, stem cell
- MeSH Terms
-
- Acute Kidney Injury/chemically induced
- Acute Kidney Injury/pathology*
- Acute Kidney Injury/therapy
- Animals
- Disease Models, Animal
- Glomerulonephritis/genetics
- Glomerulonephritis/pathology*
- Glomerulonephritis/therapy
- Humans
- Kidney Diseases, Cystic/genetics
- Kidney Diseases, Cystic/pathology*
- Kidney Diseases, Cystic/therapy
- Nephrons/embryology
- Nephrons/pathology*
- Organogenesis
- Regeneration
- Zebrafish/physiology*
- PubMed
- 27165832 Full text @ Kidney Int.
Citation
Poureetezadi, S.J., Wingert, R.A. (2016) Little fish, big catch: zebrafish as a model for kidney disease. Kidney International. 89(6):1204-10.
Abstract
The zebrafish, Danio rerio, is a relevant vertebrate model for biomedical research and translational studies because of its broad genetic conservation with humans. In recent years, scientists have formulated a growing list of zebrafish kidney disease paradigms, the study of which has contributed a multitude of insights into the basic biology of human conditions and even identified potential therapeutic agents. Conversely, there are also distinctive aspects of zebrafish biology lacking in higher vertebrates, such as the capacity to heal without lasting scar formation after tissue damage and the ability to generate nephrons throughout their lifespan, which makes the zebrafish uniquely suited to study regeneration in the context of the kidney. Here, we review several informative zebrafish models of kidney disease and discuss their future applications in nephrology.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping