PUBLICATION
Effects of inorganic mercury on the olfactory pits of zebrafish larvae
- Authors
- MacDonald, T.C., Sylvain, N.J., James, A.K., Pickering, I.J., Krone, P.H., George, G.N.
- ID
- ZDB-PUB-160426-5
- Date
- 2016
- Source
- Metallomics : integrated biometal science 8(5): 514-7 (Journal)
- Registered Authors
- Krone, Patrick H.
- Keywords
- none
- MeSH Terms
-
- Animals
- Larva/drug effects*
- Mercury/toxicity*
- Spectrometry, X-Ray Emission
- Zebrafish/anatomy & histology
- Zebrafish/growth & development*
- PubMed
- 27108745 Full text @ Metallomics
Citation
MacDonald, T.C., Sylvain, N.J., James, A.K., Pickering, I.J., Krone, P.H., George, G.N. (2016) Effects of inorganic mercury on the olfactory pits of zebrafish larvae. Metallomics : integrated biometal science. 8(5):514-7.
Abstract
Mercury compounds are highly toxic; due to the rising levels of mercury pollution, both human and environmental exposure to mercury are increasing. Occupational exposure to inhaled mercury can be high, causing adverse effects not only in the lungs, but in the olfactory system as well. Olfaction plays a critical role in the survival of fish and other vertebrates, and impaired olfaction can substantially impact human quality of life. We present a study of the effects of mercury exposure in the olfactory pits of zebrafish larvae using a combination of X-ray fluorescence imaging and immunohistochemistry. We show that mercury accumulates in the sensory cells of the olfactory pits and also that it may also damage primary neurons, such as those that innervate olfactory pits.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping