ZFIN ID: ZDB-PERS-960805-307
Krone, Patrick H.
Email: pat.krone@usask.ca
URL: http://www.usask.ca/anatomy/#Areas of Research
Affiliation: Krone Lab
Address: Department of Anatomy and Cell Biology University of Saskatchewan 107 Wiggins Road Saskatoon, Saskatchewan, S7N 5E5 Canada
Country: Canada
Phone: (306) 966-4089
Fax: (306) 966-4298


Dolgova, N.V., Nehzati, S., MacDonald, T.C., Summers, K.L., Crawford, A.M., Krone, P.H., George, G.N., Pickering, I.J. (2019) Disruption of selenium transport and function is a major contributor to mercury toxicity in zebrafish larvae. Metallomics : integrated biometal science. 11(3):621-631
MacDonald, T.C., Sylvain, N.J., James, A.K., Pickering, I.J., Krone, P.H., George, G.N. (2016) Effects of inorganic mercury on the olfactory pits of zebrafish larvae. Metallomics : integrated biometal science. 8(5):514-7
Dolgova, N.V., Hackett, M.J., MacDonald, T.C., Nehzati, S., James, A.K., Krone, P.H., George, G.N., Pickering, I.J. (2016) Distribution of selenium in zebrafish larvae after exposure to organic and inorganic selenium forms. Metallomics : integrated biometal science. 8(3):305-12
MacDonald, T.C., Nehzati, S., Sylvain, N.J., James, A.K., Korbas, M., Caine, S., Pickering, I.J., George, G.N., Krone, P.H. (2015) Phenylthiourea alters toxicity of mercury compounds in zebrafish larvae. Journal of inorganic biochemistry. 151:10-17
Choudhury, S., Thomas, J.K., Sylvain, N.J., Ponomarenko, O., Gordon, R.A., Heald, S.M., Janz, D.M., Krone, P.H., Coulthard, I., George, G.N., Pickering, I.J. (2015) Selenium preferentially accumulates in the eye lens following embryonic exposure: a confocal X-ray fluorescence imaging study. Environmental science & technology. 49(4):2255-61
Korbas, M., Lai, B., Vogt, S., Gleber, S.C., Karunakaran, C., Pickering, I.J., Krone, P.H., and George, G.N. (2013) Methylmercury Targets Photoreceptor Outer Segments. ACS Chemical Biology. 8(10):2256-63
Swan, C.L., Evans, T.G., Sylvain, N., and Krone, P.H. (2012) Zebrafish HSF4: a novel protein that shares features of both HSF1 and HSF4 of mammals. Cell stress & chaperones. 17(5):623-637
Korbas, M., Macdonald, T.C., Pickering, I.J., George, G.N., and Krone, P.H. (2012) Chemical Form Matters: Differential Accumulation of Mercury Following Inorganic and Organic Mercury Exposures in Zebrafish Larvae. ACS Chemical Biology. 7(2):411-420
Korbas, M., Krone, P.H., Pickering, I.J., and George, G.N. (2010) Dynamic accumulation and redistribution of methylmercury in the lens of developing zebrafish embryos and larvae. Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry. 15(7):1137-1145
Korbas, M., Blechinger, S.R., Krone, P.H., Pickering, I.J., and George, G.N. (2008) Localizing organomercury uptake and accumulation in zebrafish larvae at the tissue and cellular level. Proceedings of the National Academy of Sciences of the United States of America. 105(34):12108-12112
Blechinger, S.R., Kusch, R.C., Haugo, K., Matz, C., Chivers, D.P., and Krone, P.H. (2007) Brief embryonic cadmium exposure induces a stress response and cell death in the developing olfactory system followed by long-term olfactory deficits in juvenile zebrafish. Toxicology and applied pharmacology. 224(1):72-80
Mackay, A.B., Mhanni, A.A., McGowan, R.A., and Krone, P.H. (2007) Immunological detection of changes in genomic DNA methylation during early zebrafish development. Genome. 50(8):778-785
Matz, C.J., and Krone, P.H. (2007) Cell death, stress-responsive transgene activation, and deficits in the olfactory system of larval zebrafish following cadmium exposure. Environmental science & technology. 41(14):5143-5148
Matz, C.J., Treble, R.G., and Krone, P.H. (2007) Accumulation and elimination of cadmium in larval stage zebrafish following acute exposure. Ecotoxicology and environmental safety. 66(1):44-48
Evans, T.G., Belak, Z., Ovsenek, N., and Krone, P.H. (2007) Heat shock factor 1 is required for constitutive Hsp70 expression and normal lens development in embryonic zebrafish. Comparative biochemistry and physiology. Part A, Molecular & integrative physiology. 146(1):131-140
Krone, P.H., Blechinger, S.R., Evans, T.G., Ryan, J.A., Noonan, E.J., and Hightower, L.E. (2005) Use of fish liver PLHC-1 cells and zebrafish embryos in cytotoxicity assays. Methods (San Diego, Calif.). 35(2):176-187
Evans, T.G., Yamamoto, Y., Jeffery, W.R., and Krone, P.H. (2005) Zebrafish Hsp70 is required for embryonic lens formation. Cell stress & chaperones. 10(1):66-78
Krone, P.H., Evans, T.G., and Blechinger, S.R. (2003) Heat shock gene expression and function during zebrafish embryogenesis. Seminars in cell & developmental biology. 14(5):267-274
Blechinger, S.R., Warren, J.T., Kuwada, J.Y., and Krone, P.H. (2002) Developmental toxicology of cadmium in living embryos of a stable transgenic zebrafish line. Environmental health perspectives. 119(19):1041-1046
Martin, C.C., Tsang, C.H., Beiko, R.G., and Krone, P.H. (2002) Expression and genomic organization of the zebrafish chaperonin gene complex. Genome. 45(5):804-811
Blechinger, S.R., Evans, T.G., Tang, P.T., Kuwada, J.Y., Warren, J.T., and Krone, P.H. (2002) The heat-inducible zebrafish hsp70 gene is expressed during normal lens development under non-stress conditions. Mechanisms of Development. 112(1-2):213-215
Willey, J.B. and Krone, P.H. (2001) Effects of endosulfan and nonylphenol on the primordial germ cell population in pre-larval zebrafish embryos. Aquatic toxicology (Amsterdam, Netherlands). 54(1-2):113-123
Martin, C.C., Tang, P., Barnardo, G., and Krone, P.H. (2001) Expression of the chaperonin 10 gene during zebrafish development. Cell stress & chaperones. 6(1):38
Halloran, M.C., Sato-Maeda, M., Warren, J.T., Su, F., Lele, Z., Krone, P.H., Kuwada, J.Y., and Shoji, W. (2000) Laser-induced gene expression in specific cells of transgenic zebrafish. Development (Cambridge, England). 127(9):1953-1960
Adam, A., Bartfai, R., Lele, Z., Krone, P.H., and Orbán, L. (2000) Heat-inducible expression of a reporter gene detected by transient assay in zebrafish. Experimental cell research. 256(1):282-290
Sass, J.B., Martin, C.C., and Krone, P.H. (1999) Restricted expression of the zebrafish hsp90alpha gene in slow and fast muscle fiber lineages. The International journal of developmental biology. 43(8):835-838
Lele, Z., Hartson, S.D., Martin, C.C., Whitesell, L., Matts, R.L., and Krone, P.H. (1999) Disruption of zebrafish somite development by pharmacologic inhibition of hsp90. Developmental Biology. 210(1):56-70
Sass, J.B. and Krone, P.H. (1997) HSP90alpha gene expression may be a conserved feature of vertebrate somitogenesis. Experimental cell research. 233(2):391-394
Lele, Z., S. Engel, and P.H. Krone (1997) hsp47 and hsp70 gene expression is differentially regulated in a stress- and tissue-specific manner in zebrafish embryos. Developmental genetics. 21(2):123-133
Lele, Z. and Krone, P.H. (1997) Expression of genes encoding the collegen-binding heat shock protein (Hsp47) and type II collagen in developing zebrafish embryos. Mechanisms of Development. 61(1-2):89-98
Krone, P.H., Sass, J.B., and Lele, Z. (1997) Heat shock protein gene expression during embryonic development of the zebrafish. Cellular and molecular life sciences : CMLS. 53(1):122-129
Krone, P.H., Lele, Z., and Sass, J.B. (1997) Heat shock genes and the heat shock response in zebrafish embryos. Biochemistry and cell biology = Biochimie et biologie cellulaire. 75:487-497
Pearson, D.S., Kulyk, W.M., Kelly, G.M., and Krone, P.H. (1996) Cloning and characterization of a cDNA encoding the collagen-binding stress protein hsp47 in zebrafish. DNA and cell biology. 15:263-272
Sass, J.B., Weinberg, E.S., and Krone, P.H. (1996) Specific localization of zebrafish hsp90 alpha mRNA to myoD-expressing cells suggests a role for hsp90 alpha during normal muscle development. Mechanisms of Development. 54:195-204
Lele, Z. and Krone, P.H. (1996) The zebrafish as a model system in developmental, toxicological and transgenic research. Biotech. Adv.. 14:57-72
Krone, P.H. and Sass, J.B. (1994) hsp 90 alpha and hsp 90 beta genes are present in the zebrafish and are differentially regulated in developing embryos. Biochemical and Biophysical Research Communications. 204:746-752

Ali, A., Krone, P. H., Pearson, D. S., and Heikkila, J. J. 1996. Evaluation of stress-inducible hsp90 gene expression as a potential biomarker in Xenopus laevis. Cell Stress and Chaperones 1, 62-69.

Ali, A., Krone, P. H., and Heikkila, J.J. 1994. (dA-dC)n.(dG-dT)n repeats mark the boundaries of recent insertion event into a subgroup of Xenopus laevis hsp30 gene promoters. Genome 37, 512-515.

Krone, P.H., Snow, A., Ali, A., Pasternak, J. J., and Heikkila, J.J. 1992. Comparison of regulatory and structural regions of the Xenopus laevis small heat-shock protein-encoding gene family. Gene 110, 159-166.