PUBLICATION
Pax7 is required for establishment of the xanthophore lineage in zebrafish embryos
- Authors
- Nord, H., Dennhag, N., Muck, J., von Hofsten, J.
- ID
- ZDB-PUB-160408-4
- Date
- 2016
- Source
- Molecular biology of the cell 27(11): 1853-62 (Journal)
- Registered Authors
- Muck, Joscha, Nord, Hanna, von Hofsten, Jonas
- Keywords
- none
- MeSH Terms
-
- Animals
- Body Patterning/genetics
- Body Patterning/physiology
- Cell Differentiation/genetics
- Chromatophores
- Embryo, Nonmammalian/metabolism
- Gene Expression Regulation, Developmental
- Melanophores/metabolism
- Neural Crest/metabolism
- PAX2 Transcription Factor/genetics*
- PAX2 Transcription Factor/metabolism*
- Pigmentation/genetics*
- Pigmentation/physiology
- Zebrafish/genetics
- Zebrafish Proteins/genetics*
- Zebrafish Proteins/metabolism*
- PubMed
- 27053658 Full text @ Mol. Biol. Cell
Citation
Nord, H., Dennhag, N., Muck, J., von Hofsten, J. (2016) Pax7 is required for establishment of the xanthophore lineage in zebrafish embryos. Molecular biology of the cell. 27(11):1853-62.
Abstract
The pigment pattern of many animal species is a result of the arrangement of different types of pigment producing chromatophores. The zebrafish have three different types of chromatophores; black melanophores, yellow xanthophores and shimmering iridophores arranged in a characteristic pattern of golden and blue horizontal stripes. In the zebrafish embryo chromatophores derive from the neural crest cells. Using pax7a and pax7b zebrafish mutants we have identified a previously unknown requirement for Pax7 in the xanthophore lineage formation. The absence of Pax7 results in a severe reduction of xanthophore precursor cells and a complete depletion of differentiated xanthophores in embryos as well as adult zebrafish. In contrast, the melanophore lineage is increased in pax7a/pax7b double mutant embryos and larvae, whereas juvenile and adult pax7a/pax7b double mutant zebrafish display a severe decrease in melanophores and a pigment pattern disorganisation, indicative of a xanthophore deficient phenotype. In summary, we propose a novel role for Pax7 in the early specification of chromatophore precursor cells.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping