ZFIN ID: ZDB-PUB-160317-8
Insights into kidney stem cell development and regeneration using zebrafish
Drummond, B.E., Wingert, R.A.
Date: 2016
Source: World journal of stem cells   8: 22-31 (Review)
Registered Authors: Drummond, Bridgette, Wingert, Rebecca
Keywords: Blood filter, Kidney, Nephron, Regeneration, Renal corpuscle, Renal progenitor, Renal stem cell, Tubule
MeSH Terms: none
PubMed: 26981168 Full text @ World J Stem Cells
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ABSTRACT
Kidney disease is an escalating global health problem, for which the formulation of therapeutic approaches using stem cells has received increasing research attention. The complexity of kidney anatomy and function, which includes the diversity of renal cell types, poses formidable challenges in the identification of methods to generate replacement structures. Recent work using the zebrafish has revealed their high capacity to regenerate the integral working units of the kidney, known as nephrons, following acute injury. Here, we discuss these findings and explore the ways that zebrafish can be further utilized to gain a deeper molecular appreciation of renal stem cell biology, which may uncover important clues for regenerative medicine.
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