PUBLICATION

Zebrafish Reel in Phenotypic Suppressors of Autism

Authors
Biran, J., Levkowitz, G.
ID
ZDB-PUB-160219-8
Date
2016
Source
Neuron   89: 673-675 (Review)
Registered Authors
Biran, Jacob, Levkowitz, Gil
Keywords
none
MeSH Terms
  • Animals
  • Autistic Disorder/drug therapy*
  • Estrogens/pharmacology*
  • Gene Expression Regulation/drug effects*
  • Gene Expression Regulation/genetics*
  • Humans
  • Membrane Proteins/genetics*
  • Mutation/genetics*
  • Nerve Tissue Proteins/genetics*
PubMed
26889805 Full text @ Neuron
Abstract
Chemical genetics can help decipher novel pathways underlying neurodevelopmental psychiatric impairments. Hoffman et al. (2016) utilized behavioral profiling of psychoactive compounds in zebrafish and identified estrogens as suppressors of a phenotype resulting from loss of an autism risk gene.
Genes / Markers
Figures
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Antibodies
Orthology
Engineered Foreign Genes
Mapping