ZFIN ID: ZDB-PUB-150912-2
Zebrafish as tools for drug discovery
MacRae, C.A., Peterson, R.T.
Date: 2015
Source: Nature reviews. Drug discovery   14(10): 721-31 (Review)
Registered Authors: MacRae, Calum A., Peterson, Randall
Keywords: Drug safety, Phenotypic screening, Zebrafish
MeSH Terms:
  • Animals
  • Drug Discovery*
  • Drug Evaluation, Preclinical
  • Embryo, Nonmammalian/drug effects
  • Humans
  • Models, Animal
  • Pyrazoles/pharmacology
  • Pyrimidines/pharmacology
  • Zebrafish*/embryology
  • Zebrafish*/physiology
PubMed: 26361349 Full text @ Nat. Rev. Drug Discov.
The zebrafish has become a prominent vertebrate model for disease and has already contributed to several examples of successful phenotype-based drug discovery. For the zebrafish to become useful in drug development more broadly, key hurdles must be overcome, including a more comprehensive elucidation of the similarities and differences between human and zebrafish biology. Recent studies have begun to establish the capabilities and limitations of zebrafish for disease modelling, drug screening, target identification, pharmacology, and toxicology. As our understanding increases and as the technologies for manipulating zebrafish improve, it is hoped that the zebrafish will have a key role in accelerating the emergence of precision medicine.