ZFIN ID: ZDB-PERS-001205-1
Peterson, Randall
Email: randall.peterson@pharm.utah.edu
Affiliation: Randall Peterson Lab
Address: College of Pharmacy University of Utah 30 South 2000 East Salt Lake City, UT 84112
Country: United States
Phone: 801-581-3402


Parvez, S., Zhang, T., Peterson, R.T. (2024) Scalable CRISPR Screens in Zebrafish Using MIC-Drop. Methods in molecular biology (Clifton, N.J.). 2707:319334319-334
Sampieri, A., Padilla-Flores, T., Thawani, A.R., Lam, P.Y., Fuchter, M.J., Peterson, R., Vaca, L. (2023) The conducting state of TRPA1 modulates channel lateral mobility. Cell Calcium. 116:102800102800
Pluimer, B.R., Harrison, D.L., Boonyavairoje, C., Prinssen, E.P., Rogers-Evans, M., Peterson, R.T., Thyme, S.B., Nath, A.K. (2023) Behavioral analysis through the lifespan of disc1 mutant zebrafish identifies defects in sensorimotor transformation. iScience. 26:107099107099
Zhang, T., Alonzo, I., Stubben, C., Geng, Y., Herdman, C., Chandler, N., Doane, K.P., Pluimer, B.R., Trauger, S.A., Peterson, R.T. (2023) A zebrafish model of Combined Saposin Deficiency identifies acid sphingomyelinase as a potential therapeutic target. Disease models & mechanisms. 16(7):
Parvez, S., Brandt, Z.J., Peterson, R.T. (2023) Large-scale F0 CRISPR screens in vivo using MIC-Drop. Nature Protocols. 18(6):1841-1865
Geng, Y., Yates, C., Peterson, R.T. (2023) Social behavioral profiling by unsupervised deep learning reveals a stimulative effect of dopamine D3 agonists on zebrafish sociality. Cell reports methods. 3:100381100381
Geng, Y., Zhang, T., Alonzo, I.G., Godar, S.C., Yates, C., Pluimer, B.R., Harrison, D.L., Nath, A.K., Yeh, J.J., Drummond, I.A., Bortolato, M., Peterson, R.T. (2022) Top2a promotes the development of social behavior via PRC2 and H3K27me3. Science advances. 8:eabm7069eabm7069
Behymer, M.M., Mo, H., Fujii, N., Suresh, V., Chan, A., Lee, J., Nath, A.K., Saha, K., Mahon, S.B., Brenner, M., MacRae, C.A., Peterson, R., Boss, G.R., Knipp, G.T., Davisson, V.J. (2022) Identification of Platinum(II) Sulfide Complexes Suitable as Intramuscular Cyanide Countermeasures. Chemical Research in Toxicology. 35(11):1983-1996
MacRae, C.A., Peterson, R.T. (2022) Zebrafish as a Mainstream Model for In Vivo Systems Pharmacology and Toxicology. Annual Review of Pharmacology and Toxicology. 63:43-64
Nielson, J.R., Nath, A.K., Doane, K.P., Shi, X., Lee, J., Tippetts, E.G., Saha, K., Morningstar, J., Hicks, K.G., Chan, A., Zhao, Y., Kelly, A., Hendry-Hofer, T.B., Witeof, A., Sips, P.Y., Mahon, S., Bebarta, V.S., Davisson, V.J., Boss, G.R., Rutter, J., MacRae, C.A., Brenner, M., Gerszten, R.E., Peterson, R.T. (2022) Glyoxylate protects against cyanide toxicity through metabolic modulation. Scientific Reports. 12:4982
Carmack, S.A., Vendruscolo, J.C.M., Adrienne McGinn, M., Miranda-Barrientos, J., Repunte-Canonigo, V., Bosse, G.D., Mercatelli, D., Giorgi, F.M., Fu, Y., Hinrich, A.J., Jodelka, F.M., Ling, K., Messing, R.O., Peterson, R.T., Rigo, F., Edwards, S., Sanna, P.P., Morales, M., Hastings, M.L., Koob, G.F., Vendruscolo, L.F. (2022) Corticosteroid sensitization drives opioid addiction. Molecular psychiatry. 27(5):2492-2501
Geng, Y., Peterson, R.T. (2021) Rapid Mounting of Zebrafish Larvae for Brain Imaging. Zebrafish. 18:376-379
Parvez, S., Herdman, C., Beerens, M., Chakraborti, K., Harmer, Z.P., Yeh, J.J., MacRae, C.A., Yost, H.J., Peterson, R.T. (2021) MIC-Drop: A platform for large-scale in vivo CRISPR screens. Science (New York, N.Y.). 373(6559):1146-1151
Bosse, G.D., Cadeddu, R., Floris, G., Farero, R.D., Vigato, E., Lee, S.J., Zhang, T., Gaikwad, N.W., Keefe, K.A., Phillips, P.E., Bortolato, M., Peterson, R.T. (2021) The 5α-reductase inhibitor finasteride reduces opioid self-administration in animal models of opioid use disorder. The Journal of Clinical Investigation. 131(10):
Wu, G., Dentinger, B.T.M., Nielson, J.R., Peterson, R.T., Winter, J.M. (2021) Emerimicins V-X, 15-Residue Peptaibols Discovered from an Acremonium sp. through Integrated Genomic and Chemical Approaches. Journal of natural products. 84(4):1113-1126
Jin, Y.N., Peterson, R.T. (2021) Chemical Genetics: Manipulating the Germline with Small Molecules. Methods in molecular biology (Clifton, N.J.). 2218:61-73
Lam, P.Y., Thawani, A.R., Balderas, E., White, A.J.P., Chaudhuri, D., Fuchter, M.J., Peterson, R. (2020) TRPswitch - a step function chemo-optogenetic ligand for the vertebrate TRPA1 channel. Journal of the American Chemical Society. 142(41):17457-17468
Goldshtein, H., Muhire, A., Petel Légaré, V., Pushett, A., Rotkopf, R., Shefner, J.M., Peterson, R.T., Armstrong, G.A.B., Russek-Blum, N. (2020) Efficacy of Ciprofloxacin/Celecoxib combination in zebrafish models of amyotrophic lateral sclerosis. Annals of clinical and translational neurology. 7(10):1883-1897
Weeks, O., Bossé, G.D., Oderberg, I.M., Akle, S., Houvras, Y., Wrighton, P.J., LaBella, K., Iversen, I., Tavakoli, S., Adatto, I., Schwartz, A., Kloosterman, D., Tsomides, A., Charness, M.E., Peterson, R.T., Steinhauser, M.L., Fazeli, P.K., Goessling, W. (2020) Fetal alcohol spectrum disorder predisposes to metabolic abnormalities in adulthood. The Journal of Clinical Investigation. 130(5):2252-2269
Amgalan, D., Garner, T.P., Pekson, R., Jia, X.F., Yanamandala, M., Paulino, V., Liang, F.G., Corbalan, J.J., Lee, J., Chen, Y., Karagiannis, G.S., Sanchez, L.R., Liang, H., Narayanagari, S.R., Mitchell, K., Lopez, A., Margulets, V., Scarlata, M., Santulli, G., Asnani, A., Peterson, R.T., Hazan, R.B., Condeelis, J.S., Oktay, M.H., Steidl, U., Kirshenbaum, L.A., Gavathiotis, E., Kitsis, R.N. (2020) A small-molecule allosteric inhibitor of BAX protects against doxorubicin-induced cardiomyopathy. Nature cancer. 1:315-328
Lam, P.Y., Kutchukian, P., Anand, R., Imbriglio, J., Andrews, C., Padilla, H., Vohra, A., Lane, S., Parker, D.L., Taracido, I.C., Johns, D.G., Beerens, M., MacRae, C.A., Caldwell, J., Sorota, S., Asnani, A., Peterson, R.T. (2020) Cyp1 inhibition prevents doxorubicin-induced cardiomyopathy in a zebrafish heart failure model. Chembiochem : a European journal of chemical biology. 21(13):1905-1910
Nath, A.K., Ma, J., Chen, Z.Z., Li, Z., Vitery, M.D.C., Kelley, M.L., Peterson, R.T., Gerszten, R.E., Yeh, J.J. (2020) Genetic deletion of gpr27 alters acylcarnitine metabolism, insulin sensitivity, and glucose homeostasis in zebrafish. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 34:1546-1557
Zhang, T., Trauger, S.A., Vidoudez, C., Doane, K.P., Pluimer, B.R., Peterson, R.T. (2019) Parallel Reaction Monitoring reveals structure-specific ceramide alterations in the zebrafish. Scientific Reports. 9:19939
Tu, J., Svatunek, D., Parvez, S., Eckvahl, H.J., Xu, M., Peterson, R.T., Houk, K.N., Franzini, R.M. (2019) Isonitrile-responsive and bioorthogonally removable tetrazine protecting groups. Chemical science. 11:169-179
Cassar, S., Adatto, I., Freeman, J.L., Gamse, J.T., Iturria, I., Lawrence, C., Muriana, A., Peterson, R., Van Cruchten, S., Zon, L. (2019) Use of Zebrafish in Drug Discovery Toxicology. Chemical Research in Toxicology. 33(1):95-118
McCarroll, M.N., Gendelev, L., Kinser, R., Taylor, J., Bruni, G., Myers-Turnbull, D., Helsell, C., Carbajal, A., Rinaldi, C., Kang, H.J., Gong, J.H., Sello, J.K., Tomita, S., Peterson, R.T., Keiser, M.J., Kokel, D. (2019) Zebrafish behavioural profiling identifies GABA and serotonin receptor ligands related to sedation and paradoxical excitation. Nature communications. 10:4078
Geng, Y., Peterson, R.T. (2019) The zebrafish subcortical social brain as a model for studying social behavior disorders. Disease models & mechanisms. 12(8)
Lam, P.Y., Peterson, R.T. (2019) Developing zebrafish disease models for in vivo small molecule screens. Current Opinion in Chemical Biology. 50:37-44
Jordi, J., Guggiana-Nilo, D., Bolton, A.D., Prabha, S., Ballotti, K., Herrera, K., Rennekamp, A.J., Peterson, R.T., Lutz, T.A., Engert, F. (2018) High-throughput screening for selective appetite modulators: A multibehavioral and translational drug discovery strategy. Science advances. 4:eaav1966
Morningstar, J., Lee, J., Hendry-Hofer, T., Witeof, A., Lyle, L.T., Knipp, G., MacRae, C.A., Boss, G.R., Peterson, R.T., Davisson, V.J., Gerszten, R.E., Bebarta, V.S., Mahon, S., Brenner, M., Nath, A.K. (2018) Intramuscular administration of hexachloroplatinate reverses cyanide-induced metabolic derangements and counteracts severe cyanide poisoning.. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 1:81-92
Jin, Y.N., Schlueter, P.J., Jurisch-Yaksi, N., Lam, P.Y., Jin, S., Hwang, W.Y., Yeh, J.J., Yoshigi, M., Ong, S.E., Schenone, M., Hartigan, C.R., Carr, S.A., Peterson, R.T. (2018) Noncanonical translation via deadenylated 3' UTRs maintains primordial germ cells. Nature Chemical Biology. 14(9):844-852
Tu, J., Xu, M., Parvez, S., Peterson, R.T., Franzini, R.M. (2018) Bioorthogonal Removal of 3-Isocyanopropyl Groups Enables the Controlled Release of Fluorophores and Drugs in Vivo. Journal of the American Chemical Society. 140(27):8410-8414
Basu, S., Jalodia, K., Ranjan, S., Yeh, J.J., Peterson, R.T., Sachidanandan, C. (2018) Small molecule inhibitors of NFkB reverse iron overload and hepcidin deregulation in a zebrafish model for Hereditary Hemochromatosis Type 3. ACS Chemical Biology. 13(8):2143-2152
Sips, P.Y., Shi, X., Musso, G., Nath, A.K., Zhao, Y., Nielson, J., Morningstar, J., Kelly, A.E., Mikell, B., Buys, E., Bebarta, V., Rutter, J., Davisson, V.J., Mahon, S., Brenner, M., Boss, G.R., Peterson, R.T., Gerszten, R.E., MacRae, C.A. (2018) Identification of specific metabolic pathways as druggable targets regulating the sensitivity to cyanide poisoning. PLoS One. 13:e0193889
Asnani, A., Zheng, B., Liu, Y., Wang, Y., Chen, H.H., Vohra, A., Chi, A., Cornella-Taracido, I., Wang, H., Johns, D.G., Sosnovik, D.E., Peterson, R.T. (2018) Highly potent visnagin derivatives inhibit Cyp1 and prevent doxorubicin cardiotoxicity. JCI insight. 3(1)
Bossé, G.D., Peterson, R.T. (2017) Development of an opioid self-administration assay to study drug seeking in zebrafish. Behavioural brain research. 335:158-166
Lam, P.Y., Mendu, S.K., Mills, R.W., Zheng, B., Padilla, H., Milan, D.J., Desai, B.N., Peterson, R.T. (2017) A high-conductance chemo-optogenetic system based on the vertebrate channel Trpa1b. Scientific Reports. 7:11839
Wu, G., Nielson, J.R., Peterson, R.T., Winter, J.M. (2017) Bonnevillamides, Linear Heptapeptides Isolated from a Great Salt Lake-Derived Streptomyces sp. Marine drugs. 15(7)
Nath, A.K., Shi, X., Harrison, D.L., Morningstar, J.E., Mahon, S., Chan, A., Sips, P., Lee, J., MacRae, C.A., Boss, G.R., Brenner, M., Gerszten, R.E., Peterson, R.T. (2017) Cisplatin Analogs Confer Protection against Cyanide Poisoning. Cell chemical biology. 24(5):565-575.e4
Kimberly, W.T., O’Sullivan, J., Nath, A.K., Keyes, M., Yang, Q., Larson, M.G., Ramachandran, V., Peterson, R.T., Wang, T.J., Corey, .K, Gerszten, R.E. (2017) Metabolite profiling identifies anandamide as a biomarker of nonalcoholic steatohepatitis. JCI insight. 2(9)
Noonan, H.R., Metelo, A.M., Kamei, C.N., Peterson, R.T., Drummond, I.A., Iliopoulos, O. (2016) Loss of vhl in the zebrafish pronephros recapitulates early stages of human clear cell renal cell carcinoma. Disease models & mechanisms. 9:873-884
Bruni, G., Rennekamp, A.J., Velenich, A., McCarroll, M., Gendelev, L., Fertsch, E., Taylor, J., Lakhani, P., Lensen, D., Evron, T., Lorello, P.J., Huang, X.P., Kolczewski, S., Carey, G., Caldarone, B.J., Prinssen, E., Roth, B.L., Keiser, M.J., Peterson, R.T., Kokel, D. (2016) Zebrafish behavioral profiling identifies multitarget antipsychotic-like compounds. Nature Chemical Biology. 12(7):559-66
Rennekamp, A.J., Huang, X.P., Wang, Y., Patel, S., Lorello, P.J., Cade, L., Gonzales, A.P., Yeh, J.J., Caldarone, B.J., Roth, B.L., Kokel, D., Peterson, R.T. (2016) σ1 receptor ligands control a switch between passive and active threat responses. Nature Chemical Biology. 12(7):552-8
Li, X., Rhee, D.K., Malhotra, R., Mayeur, C., Hurst, L.A., Ager, E., Shelton, G., Kramer, Y., McCulloh, D., Keefe, D., Bloch, K.D., Bloch, D.B., Peterson, R.T. (2016) Progesterone receptor membrane component-1 regulates hepcidin biosynthesis. The Journal of Clinical Investigation. 126(1):389-401
Brady, C.A., Rennekamp, A.J., Peterson, R.T. (2016) Chemical Screening in Zebrafish. Methods in molecular biology (Clifton, N.J.). 1451:3-16
Palchaudhuri, R., Lambrecht, M.J., Botham, R.C., Partlow, K.C., van Ham, T.J., Putt, K.S., Nguyen, L.T., Kim, S.H., Peterson, R.T., Fan, T.M., Hergenrother, P.J. (2015) A Small Molecule that Induces Intrinsic Pathway Apoptosis with Unparalleled Speed. Cell Reports. 13:2027-36
MacRae, C.A., Peterson, R.T. (2015) Zebrafish as tools for drug discovery. Nature reviews. Drug discovery. 14(10):721-31
Kleinstiver, B.P., Prew, M.S., Tsai, S.Q., Topkar, V.V., Nguyen, N.T., Zheng, Z., Gonzales, A.P., Li, Z., Peterson, R.T., Yeh, J.J., Aryee, M.J., Joung, J.K. (2015) Engineered CRISPR-Cas9 nucleases with altered PAM specificities. Nature. 523(7561):481-5
Vardy, E., Sassano, M.F., Rennekamp, A.J., Kroeze, W.K., Mosier, P.D., Westkaemper, R.B., Stevens, C.W., Katritch, V., Stevens, R.C., Peterson, R.T., Roth, B.L. (2015) Single Amino Acid Variation Underlies Species-Specific Sensitivity to Amphibian Skin-Derived Opioid-like Peptides. Chemistry & Biology. 22:764-75
Martins Metelo, A., Noonan, H.R., Xiang, L., Jin, Y., Baker, R., Kamentsky, L., Zhang, Y., van Rooijen, E., Shin, J., Carpenter, A.E., Yeh, J.R., Peterson, R.T., Iliopoulos, O. (2015) Pharmacological HIF2α inhibition improves VHL disease–associated phenotypes in zebrafish model. J. Clin. Invest.. 125(5):1987-97
Nath, A.K., Ryu, J.H., Jin, Y.N., Roberts, L.D., Dejam, A., Gerszten, R.E., Peterson, R.T. (2015) PTPMT1 Inhibition Lowers Glucose through Succinate Dehydrogenase Phosphorylation. Cell Reports. 10(5):694-701
Rennekamp, A.J., Peterson, R.T. (2015) 15 years of zebrafish chemical screening. Current Opinion in Chemical Biology. 24C:58-70
Liu, Y., Asnani, A., Zou, L., Bentley, V.L., Yu, M., Wang, Y., Dellaire, G., Sarkar, K.S., Dai, M., Chen, H.H., Sosnovik, D.E., Shin, J.T., Haber, D.A., Berman, J.N., Chao, W., Peterson, R.T. (2014) Visnagin protects against doxorubicin-induced cardiomyopathy through modulation of mitochondrial malate dehydrogenase. Science Translational Medicine. 6:266ra170
Hwang, W.Y., Peterson, R.T., Yeh, J.R. (2014) Methods for targeted mutagenesis in zebrafish using TALENs. Methods (San Diego, Calif.). 69(1):76-84
van Ham, T.J., Brady, C.A., Kalicharan, R.D., Oosterhof, N., Kuipers, J., Veenstra-Algra, A., Sjollema, K.A., Peterson, R.T., Kampinga, H.H., Giepmans, B.N. (2014) Intravital correlated microscopy reveals differential macrophage and microglial dynamics during resolution of neuroinflammation. Disease models & mechanisms. 7:857-869
Burger, A., Vasilyev, A., Tomar, R., Selig, M.K., Nielsen, G.P., Peterson, R.T., Drummond, I.A., and Haber, D.A. (2014) A zebrafish model of chordoma initiated by notochord-driven expression of HRASV12. Disease models & mechanisms. 7(7):907-13
Asnani, A., Peterson, R.T. (2014) The zebrafish as a tool to identify novel therapies for human cardiovascular disease. Disease models & mechanisms. 7:763-767
Walcott, B.P., and Peterson, R.T. (2014) Zebrafish models of cerebrovascular disease. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 34(4):571-577
Goel, S., Gupta, N., Walcott, B.P., Snuderl, M., Kesler, C.T., Kirkpatrick, N.D., Heishi, T., Huang, Y., Martin, J.D., Ager, E., Samuel, R., Wang, S., Yazbek, J., Vakoc, B.J., Peterson, R.T., Padera, T.P., Duda, D.G., Fukumura, D., and Jain, R.K. (2013) Effects of Vascular-Endothelial Protein Tyrosine Phosphatase Inhibition on Breast Cancer Vasculature and Metastatic Progression. Journal of the National Cancer Institute. 105(16):1188-1201
Hwang, W.Y., Fu, Y., Reyon, D., Maeder, M.L., Kaini, P., Sander, J.D., Joung, J.K., Peterson, R.T., and Yeh, J.R. (2013) Heritable and Precise Zebrafish Genome Editing Using a CRISPR-Cas System. PLoS One. 8(7):e68708
Zhang, Y., Wang, J., Wheat, J., Chen, X., Jin, S., Sadrzadeh, H., Fathi, A.T., Peterson, R.T., Kung, A.L., Sweetser, D.A., and Yeh, J.R. (2013) AML1-ETO mediates hematopoietic self-renewal and leukemogenesis through a COX/beta-catenin signaling pathway. Blood. 121(24):4906-16
Nath, A.K., Roberts, L.D., Liu, Y., Mahon, S.B., Kim, S., Ryu, J.H., Werdich, A., Januzzi, J.L., Boss, G.R., Rockwood, G.A., MacRae, C.A., Brenner, M., Gerszten, R.E., and Peterson, R.T. (2013) Chemical and metabolomic screens identify novel biomarkers and antidotes for cyanide exposure. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 27(5):1928-1938
Kokel, D., Cheung, C.Y., Mills, R., Coutinho-Budd, J., Huang, L., Setola, V., Sprague, J., Jin, S., Jin, Y.N., Huang, X.P., Bruni, G., Woolf, C.J., Roth, B.L., Hamblin, M.R., Zylka, M.J., Milan, D.J., and Peterson, R.T. (2013) Photochemical activation of TRPA1 channels in neurons and animals. Nature Chemical Biology. 9(4):257-263
Hwang, W.Y., Fu, Y., Reyon, D., Maeder, M.L., Tsai, S.Q., Sander, J.D., Peterson, R.T., Yeh, J.R., and Joung, J.K. (2013) Efficient genome editing in zebrafish using a CRISPR-Cas system. Nat. Biotechnol.. 31(3):227-229
Kokel, D., Dunn, T.W., Ahrens, M.B., Alshut, R., Cheung, C.Y., Saint-Amant, L., Bruni, G., Mateus, R., van Ham, T.J., Shiraki, T., Fukada, Y., Kojima, D., Yeh, J.R., Mikut, R., von Lintig, J., Engert, F., and Peterson, R.T. (2013) Identification of Nonvisual Photomotor Response Cells in the Vertebrate Hindbrain. The Journal of neuroscience : the official journal of the Society for Neuroscience. 33(9):3834-3843
Peterson, R.T., and MacRae, C.A. (2013) Changing the Scale and Efficiency of Chemical Warfare Countermeasure Discovery Using the Zebrafish. Drug Discovery Today: Disease Models. 10(1):e37–e42
Ishaq, O., Negri, J., Bray, M.A., Pacureanu, A., Peterson, R.T., and Wählby, C. (2013) Automated Quantification of Zebrafish Tail Deformation for High-Throughput Drug Screening. Proceedings IEEE International Symposium on Biomedical Imaging. 2013:902-905
Jin, S., Sarkar, K.S., Jin, Y.N., Liu, Y., Kokel, D., Van Ham, T.J., Roberts, L.D., Gerszten, R.E., MacRae, C.A., and Peterson, R.T. (2013) An In Vivo Zebrafish Screen Identifies Organophosphate Antidotes with Diverse Mechanisms of Action. Journal of Biomolecular Screening. 18(1):108-115
Cade, L., Reyon, D., Hwang, W.Y., Tsai, S.Q., Patel, S., Khayter, C., Joung, J.K., Sander, J.D., Peterson, R.T., and Yeh, J.R. (2012) Highly efficient generation of heritable zebrafish gene mutations using homo- and heterodimeric TALENs. Nucleic acids research. 40(16):8001-8010
Kokel, D., Rennekamp, A.J., Shah, A.H., Liebel, U., and Peterson, R.T. (2012) Behavioral barcoding in the cloud: embracing data-intensive digital phenotyping in neuropharmacology. Trends in Biotechnology. 30(8):421-425
van Ham, T.J., Kokel, D., and Peterson, R.T. (2012) Apoptotic Cells Are Cleared by Directional Migration and elmo1- Dependent Macrophage Engulfment. Current biology : CB. 22(9):830-836
Becker, J.R., Robinson, T.Y., Sachidanandan, C., Kelly, A.E., Coy, S., Peterson, R.T., and MacRae, C.A. (2012) In vivo natriuretic peptide reporter assay identifies chemical modifiers of hypertrophic cardiomyopathy signaling. Cardiovascular research. 93(3):463-470
Laggner, C., Kokel, D., Setola, V., Tolia, A., Lin, H., Irwin, J.J., Keiser, M.J., Cheung, C.Y., Minor, D.L., Roth, B.L., Peterson, R.T., and Shoichet, B.K. (2011) Chemical informatics and target identification in a zebrafish phenotypic screen. Nature Chemical Biology. 8(2):144-146
Sander, J.D., Cade, L., Khayter, C., Reyon, D., Peterson, R.T., Joung, J.K., and Yeh, J.R. (2011) Targeted gene disruption in somatic zebrafish cells using engineered TALENs. Nat. Biotechnol.. 29(8):697-698
Garkavtsev, I., Chauhan, V.P., Wong, H.K., Mukhopadhyay, A., Glicksman, M.A., Peterson, R.T., and Jain, R.K. (2011) Dehydro-α-lapachone, a plant product with antivascular activity. Proceedings of the National Academy of Sciences of the United States of America. 108(28):11596-601
Peal, D.S., Mills, R.W., Lynch, S.N., Mosley, J.M., Lim, E., Ellinor, P.T., January, C.T., Peterson, R.T., and Milan, D.J. (2011) Novel Chemical Suppressors of Long QT Syndrome Identified by an In Vivo Functional Screen. Circulation. 123(1):23-30
Peterson, R.T., and Fishman, M.C. (2011) Designing zebrafish chemical screens. Methods in cell biology. 105:525-541
Sander, J.D., Dahlborg, E.J., Goodwin, M.J., Cade, L., Zhang, F., Cifuentes, D., Curtin, S.J., Blackburn, J.S., Thibodeau-Beganny, S., Qi, Y., Pierick, C.J., Hoffman, E., Maeder, M.L., Khayter, C., Reyon, D., Dobbs, D., Langenau, D.M., Stupar, R.M., Giraldez, A.J., Voytas, D.F., Peterson, R.T., Yeh, J.R., Joung, J.K. (2011) Selection-free zinc-finger-nuclease engineering by context-dependent assembly (CoDA). Nature Methods. 8:67-9
Kokel, D., and Peterson, R.T. (2011) Using the zebrafish photomotor response for psychotropic drug screening. Methods in cell biology. 105:517-524
Sander, J.D., Yeh, J.R., Peterson, R.T., and Joung, J.K. (2011) Engineering zinc finger nucleases for targeted mutagenesis of zebrafish. Methods in cell biology. 104:51-58
Groeneweg, J.W., White, Y.A., Kokel, D., Peterson, R.T., Zukerberg, L.R., Berin, I., Rueda, B.R., and Wood, A.W. (2011) cables1 is required for embryonic neural development: molecular, cellular, and behavioral evidence from the zebrafish. Molecular reproduction and development. 78(1):22-32
van Ham, T.J., Mapes, J., Kokel, D., and Peterson, R.T. (2010) Live imaging of apoptotic cells in zebrafish. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 24(11):4336-4342
Peal, D.S., Peterson, R.T., and Milan, D. (2010) Small Molecule Screening in Zebrafish. Journal of cardiovascular translational research. 3(5):454-460
Das, B.C., McCartin, K., Liu, T.C., Peterson, R.T., and Evans, T. (2010) A forward chemical screen in zebrafish identifies a retinoic acid derivative with receptor specificity. PLoS One. 5(4):e10004
Ren, B., Deng, Y., Mukhopadhyay, A., Lanahan, A.A., Zhuang, Z.W., Moodie, K.L., Mulligan-Kehoe, M.J., Byzova, T.V., Peterson, R.T., and Simons, M. (2010) ERK1/2-Akt1 crosstalk regulates arteriogenesis in mice and zebrafish. J. Clin. Invest.. 120(4):1217-1228
Kokel, D., Bryan, J., Laggner, C., White, R., Cheung, C.Y., Mateus, R., Healey, D., Kim, S., Werdich, A.A., Haggarty, S.J., MacRae, C.A., Shoichet, B., and Peterson, R.T. (2010) Rapid behavior-based identification of neuroactive small molecules in the zebrafish. Nature Chemical Biology. 6(3):231-237
Zon, L.I., and Peterson, R. (2010) The new age of chemical screening in zebrafish. Zebrafish. 7(1):1
Rihel, J., Prober, D.A., Arvanites, A., Lam, K., Zimmerman, S., Jang, S., Haggarty, S.J., Kokel, D., Rubin, L.L., Peterson, R.T., and Schier, A.F. (2010) Zebrafish behavioral profiling links drugs to biological targets and rest/wake regulation. Science (New York, N.Y.). 327(5963):348-351
Milan, D.J., Kim, A.M., Winterfield, J.R., Jones, I.L., Pfeufer, A., Sanna, S., Arking, D.E., Amsterdam, A.H., Sabeh, K.M., Mably, J.D., Rosenbaum, D.S., Peterson, R.T., Chakravarti, A., Kääb, S., Roden, D.M., and MacRae, C.A. (2009) Drug-Sensitized Zebrafish Screen Identifies Multiple Genes, Including GINS3, as Regulators of Myocardial Repolarization. Circulation. 120(7):553-559
Kitambi, S.S., McCulloch, K.J., Peterson, R.T., and Malicki, J.J. (2009) Small molecule screen for compounds that affect vascular development in the zebrafish retina. Mechanisms of Development. 126(5-6):464-477
Yeh, J.R., Munson, K.M., Elagib, K.E., Goldfarb, A.N., Sweetser, D.A., and Peterson, R.T. (2009) Discovering chemical modifiers of oncogene-regulated hematopoietic differentiation. Nature Chemical Biology. 5(4):236-243
Foley, J.E., Yeh, J.R., Maeder, M.L., Reyon, D., Sander, J.D., Peterson, R.T., and Joung, J.K. (2009) Rapid mutation of endogenous zebrafish genes using zinc finger nucleases made by Oligomerized Pool ENgineering (OPEN). PLoS One. 4(2):e4348
Kokel, D., and Peterson, R.T. (2008) Chemobehavioural phenomics and behaviour-based psychiatric drug discovery in the zebrafish. Briefings in functional genomics & proteomics. 7(6):483-490
Hong, C.C., Kume, T., and Peterson, R.T. (2008) Role of crosstalk between phosphatidylinositol 3-kinase and extracellular signal-regulated kinase/mitogen-activated protein kinase pathways in artery-vein specification. Circulation research. 103(6):573-579
Peterson, R.T., Nass, R., Boyd, W.A., Freedman, J.H., Dong, K., and Narahashi, T. (2008) Use of non-mammalian alternative models for neurotoxicological study. Neurotoxicology. 29(3):545-554
Mukhopadhyay, A., and Peterson, R.T. (2008) Deciphering arterial identity through gene expression, genetics, and chemical biology. Current opinion in hematology. 15(3):221-227
Dayyani, F., Wang, J., Yeh, J.R., Ahn, E.Y., Tobey, E., Zhang, D.E., Bernstein, I.D., Peterson, R.T., and Sweetser, D.A. (2008) Loss of TLE1 and TLE4 from the del(9q) commonly deleted region in AML cooperate with AML1-ETO to affect myeloid cell proliferation and survival. Blood. 111(8):4338-4347
Yeh, J.R., Munson, K.M., Chao, Y.L., Peterson, Q.P., MacRae, C.A., and Peterson, R.T. (2008) AML1-ETO reprograms hematopoietic cell fate by downregulating scl expression. Development (Cambridge, England). 135(2):401-410
Yu, P.B., Hong, C.C., Sachidanandan, C., Babitt, J.L., Deng, D.Y., Hoyng, S.A., Lin, H.Y., Bloch, K.D., and Peterson, R.T. (2008) Dorsomorphin inhibits BMP signals required for embryogenesis and iron metabolism. Nature Chemical Biology. 4(1):33-41
Mathew, L.K., Sengupta, S., Kawakami, A., Andreasen, E.A., Löhr, C.V., Loynes, C.A., Renshaw, S.A., Peterson, R.T., and Tanguay, R.L. (2007) Unraveling tissue regeneration pathways using chemical genetics. The Journal of biological chemistry. 282(48):35202-35210
Smolen, G.A., Schott, B.J., Stewart, R.A., Diederichs, S., Muir, B., Provencher, H.L., Look, A.T., Sgroi, D.C., Peterson, R.T., and Haber, D.A. (2007) A Rap GTPase interactor, RADIL, mediates migration of neural crest precursors. Genes & Development. 21(17):2131-2136
Peterson, R.T. (2006) A noncanonical path to mechanism of action. Chemistry & Biology. 13(9):924-926
Hong, C.C., Peterson, Q.P., Hong, J.Y., and Peterson, R.T. (2006) Artery/vein specification is governed by opposing phosphatidylinositol-3 kinase and MAP kinase/ERK signaling. Current biology : CB. 16(13):1366-1372
Milan, D.J., Giokas, A.C., Serluca, F.C., Peterson, R.T., and MacRae, C.A. (2006) Notch1b and neuregulin are required for specification of central cardiac conduction tissue. Development (Cambridge, England). 133(6):1125-1132
Peterson, R.T. (2004) Discovery of therapeutic targets by phenotype-based zebrafish screens. Drug discovery today. Technologies. 1:49-54
Shafizadeh, E., Peterson, R.T., and Lin, S. (2004) Induction of reversible hemolytic anemia in living zebrafish using a novel small molecule. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. 138(3):245-249
Peterson, R.T., Shaw, S.Y., Peterson, T.A., Milan, D.J., Zhong, T.P., Schreiber, S.L., MacRae, C.A., and Fishman, M.C. (2004) Chemical suppression of a genetic mutation in a zebrafish model of aortic coarctation. Nat. Biotechnol.. 22(5):595-599
Peterson, R.T., and Fishman, M.C. (2004) Discovery and use of small molecules for probing biological processes in zebrafish. The Zebrafish: Cellular and Developmental Biology,2nd Ed. Methods Cell Biol.. 76:569-591
Milan, D.J., Peterson, T.A., Ruskin, J.N., Peterson, R.T., and MacRae, C.A. (2003) Drugs that induce repolarization abnormalities cause bradycardia in zebrafish. Circulation. 107(10):1355-1358
Peterson, R.T., Mably, J.D., Chen, J.-N., and Fishman, M.C. (2001) Convergence of distinct pathways to heart patterning reveals by the small molecule concentramide and the mutation heart-and-soul. Current biology : CB. 11:1481-1491
Peterson, R.T., Link, B.A., Dowling, J.E., and Schreiber, S.L. (2000) Small molecule developmental screens reveal the logic and timing of vertebrate development. Proceedings of the National Academy of Sciences of the United States of America. 97(24):12965-12969
Peterson, R.T. (2000) Roles for FRAP in phosphatase regulation, translation initiation, and vertebrate development. Ph.D. Thesis.